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IID50022
 UniprotP02638
ProteinProtein S100-B
GeneS100B
OrganismBos taurus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
92
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-92 Hetero tetramer : Q5E997
 Evidence X-RAY 3rm1 A Reference
       Region 3rm1 A 1-89 order
       Region 3rm1 A 90-92 disorder
Seq 1-92 Homo dimer :
 Evidence NMR 1cfp B Reference
       Region 1cfp B 1-92 order
       Region 1cfp B 90-92 high_rmsd
 Evidence NMR 1cfp A Reference
       Region 1cfp A 1-92 order
       Region 1cfp A 90-92 high_rmsd
 Evidence X-RAY 3rlz B Reference
       Region 3rlz B 1-90 order
       Region 3rlz B 91-92 disorder
 Evidence X-RAY 3rlz A Reference
       Region 3rlz A 1-90 order
       Region 3rlz A 91-92 disorder
 Evidence X-RAY 4pe7 A Reference
       Region 4pe7 A 1-92 order
 Evidence X-RAY 4pe4 X Reference
       Region 4pe4 X 1-90 order
       Region 4pe4 X 91-92 disorder
 Evidence X-RAY 4pe4 A Reference
       Region 4pe4 A 1-90 order
       Region 4pe4 A 91-92 disorder
 Evidence X-RAY 4pe1 B Reference
       Region 4pe1 B 1-90 order
       Region 4pe1 B 91-92 disorder
 Evidence X-RAY 4pe1 A Reference
       Region 4pe1 A 1-89 order
       Region 4pe1 A 90-92 disorder
 Evidence X-RAY 4pe0 X Reference
       Region 4pe0 X 1-89 order
       Region 4pe0 X 90-92 disorder
 Evidence X-RAY 4pe0 A Reference
       Region 4pe0 A 1-92 order
 Evidence X-RAY 4pdz B Reference
       Region 4pdz B 1-1 disorder
       Region 4pdz B 2-90 order
       Region 4pdz B 91-92 disorder
 Evidence X-RAY 4pdz A Reference
       Region 4pdz A 1-90 order
       Region 4pdz A 91-92 disorder
 Evidence X-RAY 1mho A Reference
       Region 1mho A 2-89 order
 Evidence X-RAY 3lle B Reference
       Region 3lle B 1-90 order
       Region 3lle B 91-92 disorder
 Evidence X-RAY 3lle A Reference
       Region 3lle A 1-90 order
       Region 3lle A 91-92 disorder
 Evidence X-RAY 3lk1 A Reference
       Region 3lk1 A 1-88 order
       Region 3lk1 A 89-90 disorder
 Evidence X-RAY 3lk0 D Reference
       Region 3lk0 D 1-90 order
 Evidence X-RAY 3lk0 C Reference
       Region 3lk0 C 1-89 order
       Region 3lk0 C 90-90 disorder
 Evidence X-RAY 3lk0 B Reference
       Region 3lk0 B 1-89 order
       Region 3lk0 B 90-90 disorder
 Evidence X-RAY 3lk0 A Reference
       Region 3lk0 A 1-89 order
       Region 3lk0 A 90-90 disorder
 Evidence X-RAY 3iqo B Reference
       Region 3iqo B 1-1 disorder
       Region 3iqo B 2-89 order
       Region 3iqo B 90-92 disorder
 Evidence X-RAY 3iqo A Reference
       Region 3iqo A 1-1 disorder
       Region 3iqo A 2-89 order
       Region 3iqo A 90-92 disorder
 Evidence X-RAY 3gk4 X Reference
       Region 3gk4 X 1-90 order
       Region 3gk4 X 91-92 disorder
 Evidence X-RAY 3gk2 A Reference
       Region 3gk2 A 1-1 disorder
       Region 3gk2 A 2-89 order
       Region 3gk2 A 90-92 disorder
 Evidence X-RAY 3gk1 A Reference
       Region 3gk1 A 1-1 disorder
       Region 3gk1 A 2-89 order
       Region 3gk1 A 90-92 disorder
 Evidence X-RAY 4fqo A Reference
       Region 4fqo A 1-89 order
 Evidence X-RAY 5er5 A Reference
       Region 5er5 A 1-90 order
       Region 5er5 A 91-92 disorder
 Evidence X-RAY 5er4 X Reference
       Region 5er4 X 1-90 order
       Region 5er4 X 91-92 disorder
 Evidence X-RAY 5dkr B Reference
       Region 5dkr B 1-90 order
       Region 5dkr B 91-92 disorder
 Evidence X-RAY 5dkr A Reference
       Region 5dkr A 1-89 order
       Region 5dkr A 90-92 disorder
 Evidence X-RAY 5dkq A Reference
       Region 5dkq A 1-91 order
       Region 5dkq A 92-92 disorder
 Evidence X-RAY 5dkn A Reference
       Region 5dkn A 1-91 order
       Region 5dkn A 92-92 disorder
 Evidence X-RAY 3cr5 X Reference
       Region 3cr5 X 1-91 order
       Region 3cr5 X 92-92 disorder
 Evidence X-RAY 3cr4 X Reference
       Region 3cr4 X 1-90 order
       Region 3cr4 X 91-92 disorder
 Evidence X-RAY 3cr2 A Reference
       Region 3cr2 A 1-90 order
       Region 3cr2 A 91-92 disorder
Seq 1-92 Hetero tetramer :
 Evidence X-RAY 3iqq A Reference
       Region 3iqq A 1-89 order
       Region 3iqq A 90-92 disorder
Seq 2-92 Hetero tetramer : IID00172Complex
 Evidence NMR 1psb A Reference
       Region 1psb A 2-92 order
 Evidence NMR 1psb B Reference
       Region 1psb B 2-92 order
       Region 1psb B 92-92 high_rmsd
Seqacetylation
    2-2 N-acetylserine
 
Prediction
NeProc
Order 1-92
AlphaFold
Disorder 91-92
Order 1-90
Pfam Hmmer
PF01023 4-47 1.5e-23
PF00036 53-81 6.7e-05
SEG 27-42
Function
Function in SwissProt
Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity (By similarity).
Biological Process
Diagram with PDB data
S100B/S100BTHE 2.0 A STRUCTURE OF HOLO S100B FROM BOVINE BRAIN