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IID50026
 UniprotO35987
ProteinNSFL1 cofactor p47
GeneNsfl1c
OrganismRattus norvegicus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
370
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-46 Monomer :
 Evidence NMR 1v92 A Reference
       Region 1v92 A 1-45 order
       Region 1v92 A 45-46 high_rmsd
Seqdisorder 46-174
 Evidence NMR Reference
       Region 46-174 disorder
Seq 171-246 Monomer :
 Evidence NMR 1vaz A Reference
       Region 1vaz A 171-246 order
       Region 1vaz A 171-177 high_rmsd
       Region 1vaz A 245-246 high_rmsd
Seq 244-370 Hetero nonamer : IID50030Complex
 Evidence X-RAY 1s3s I Reference
       Region 1s3s I 244-276 disorder
       Region 1s3s I 277-287 order
       Region 1s3s I 288-313 disorder
       Region 1s3s I 314-326 order
       Region 1s3s I 327-370 disorder
 Evidence X-RAY 1s3s H Reference
       Region 1s3s H 244-256 disorder
       Region 1s3s H 257-265 order
       Region 1s3s H 266-272 disorder
       Region 1s3s H 273-370 order
 Evidence X-RAY 1s3s G Reference
       Region 1s3s G 244-252 disorder
       Region 1s3s G 253-370 order
Seq 282-370 Monomer :
 Evidence NMR 1jru A Reference
       Region 1jru A 282-370 order
 Evidence NMR 1i42 A Reference
       Region 1i42 A 282-370 order
       Region 1i42 A 282-283 high_rmsd
Seqphosphorylation
    74-74 Phosphoserine
    102-102 Phosphoserine
    114-114 Phosphoserine
    140-140 Phosphoserine; by CDK1
    176-176 Phosphoserine
    167-167 Phosphotyrosine
    192-192 Phosphoserine
    272-272 Phosphoserine
 
Prediction
NeProc
Disorder 1-6,46-177,251-286
Order 7-45,178-244,287-370
ProS 70-81,88-132,150-160,251-257
AlphaFold
Disorder 1-1,44-92,98-102,108-113,130-131,133-152,161-161,163-164,169-178,246-251,253-254,260-271
Order 2-43,93-97,103-107,114-129,132-132,153-160,162-162,165-168,179-245,252-252,255-259,272-370
Pfam Hmmer
PF08059 184-258 2.2e-43
PF00789 290-369 2.4e-29
SEG 84-90
Function
Function in SwissProt
Reduces the ATPase activity of VCP (PubMed:9824302, PubMed:9214505). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (PubMed:12411482). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (PubMed:10930451). Inhibits the activity of CTSL (in vitro) (By similarity). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (By similarity). Also, regulates spindle orientation during mitosis (By similarity).