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IID50027
 UniprotP14585
ProteinProtein lin-12
Genelin-12
OrganismCaenorhabditis elegans
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1429
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 930-957 Hetero dimer : IID50096Complex
 Evidence X-RAY 3brd D Reference
       Region 3brd D 930-936 disorder
       Region 3brd D 937-951 order
       Region 3brd D 952-957 disorder
Seq 931-1301 Hetero trimer : IID50087Complex,IID50096Complex
 Evidence X-RAY 2fo1 E Reference
       Region 2fo1 E 931-932 disorder
       Region 2fo1 E 933-952 order
       Region 2fo1 E 953-1020 disorder
       Region 2fo1 E 1021-1297 order
       Region 2fo1 E 1298-1301 disorder
Seq 938-950 Hetero dimer :
 Evidence X-RAY 3brf D This region binds to Lag-1. Reference
       Region 3brf D 938-950 order
 
Prediction
NeProc
Disorder 813-835,894-906,930-1045,1058-1075,1297-1429
Order 1-812,836-893,907-929,1046-1057,1076-1296
ProS 813-828,906-906,930-964,981-988,993-1031,1039-1045,1058-1066,1358-1364
AlphaFold
Disorder 1-29,36-47,66-66,70-72,78-82,89-121,131-136,160-160,166-166,181-183,185-187,191-233,235-235,237-240,242-242,244-244,246-253,255-255,257-257,266-270,277-278,288-288,293-293,298-298,305-308,315-316,324-332,341-348,372-373,394-395,404-407,409-411,423-426,452-452,457-460,463-467,494-508,510-510,519-528,532-534,536-538,543-546,549-550,555-555,561-564,571-572,580-590,594-594,598-606,608-617,619-631,752-754,818-841,855-857,896-913,918-1025,1200-1200,1202-1205,1296-1429
Order 30-35,48-65,67-69,73-77,83-88,122-130,137-159,161-165,167-180,184-184,188-190,234-234,236-236,241-241,243-243,245-245,254-254,256-256,258-265,271-276,279-287,289-292,294-297,299-304,309-314,317-323,333-340,349-371,374-393,396-403,408-408,412-422,427-451,453-456,461-462,468-493,509-509,511-518,529-531,535-535,539-542,547-548,551-554,556-560,565-570,573-579,591-593,595-597,607-607,618-618,632-751,755-817,842-854,858-895,914-917,1026-1199,1201-1201,1206-1295
Pfam Hmmer
PF00008 118-149 3.4e-06
PF07645 152-189 3.1e-07
PF07974 205-245 0.00015
PF00008 254-284 9.1e-10
PF00008 291-322 2.3e-06
PF00008 327-362 1e-06
PF00008 369-401 1e-08
PF00008 408-440 1.8e-06
PF00008 462-491 0.00011
PF00008 507-540 3.3e-10
PF00008 547-578 3.5e-08
PF00008 586-618 6.2e-05
PF00066 631-669 2.7e-18
PF00066 673-710 4.5e-20
PF00066 711-750 1.9e-23
PF06816 753-808 2.9e-24
PF07684 840-901 1.6e-19
PF00023 1093-1125 1.5e-06
PF00023 1206-1239 2.2e-06
PF00023 1240-1272 4e-10
SEG 8-19 ,737-764 ,1100-1111 ,1346-1359
Function
Function in SwissProt
Involved in several cell fate decisions that require cell-cell interactions. It is possible that lin-12/Notch encodes a membrane-bound receptor for a signal that enables expression of the ventral uterine precursor cell fate. Activity in cell fate decisions and tumorigenesis is negatively regulated by sel-10. Functions in uterine cells to promote basement membrane mobility during tissue remodeling (PubMed:27661254).