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IID50028
UniprotP53044
ProteinUbiquitin fusion degradation protein 1
GeneUFD1
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
361
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-208 Monomer :
 Evidence NMR 1zc1 A Reference
       Region 1zc1 A 1-208 order
       Region 1zc1 A 1-15 high_rmsd
       Region 1zc1 A 201-208 high_rmsd
Seqphosphorylation
    354-354 Phosphoserine
 
Prediction
NeProc
Disorder 204-361
Order 1-203
ProS 241-246,252-268,285-306,322-334,355-361
AlphaFold
Disorder 6-6,9-19,34-39,200-207,209-210,213-245,248-294,296-296,298-361
Order 1-5,7-8,20-33,40-199,208-208,211-212,246-247,295-295,297-297
Pfam Hmmer
PF03152 13-199 1.3e-132
SEG 2-14 ,337-354
Function
Function in SwissProt
Functions at a post-ubiquitation step in the ubiquitin fusion degradation (UFD) pathway. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway. Required for the proteasome-dependent processing/activation of MGA2 and SPT23 transcription factors leading to the subsequent expression of OLE1. Has an additional role in the turnover of OLE1 where it targets ubiquitinated OLE1 and other proteins to the ERAD.