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IID50029
 UniprotP60670
ProteinNuclear protein localization protein 4 homolog
GeneNploc4
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
608
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-80 Hetero dimer : IID50030Complex
 Evidence NMR 2pjh A Reference
       Region 2pjh A 1-1 disorder
       Region 2pjh A 2-77 order
       Region 2pjh A 78-80 disorder
Seqacetylation
    2-2 N-acetylalanine
    179-179 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-1,83-131,565-580,600-608
Order 2-82,132-564,581-599
ProS 99-131,565-580,600-608
AlphaFold
Disorder 1-2,40-42,81-103,562-581
Order 3-39,43-80,104-561,582-608
Pfam Hmmer
PF05020 104-246 3.6e-123
PF05021 248-557 5.3e-218
SEG 59-71
Function
Function in SwissProt
The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (By similarity).