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IID50036
 UniprotQ64364
ProteinTumor suppressor ARF
GeneCdkn2a
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
169
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seqdisorder 1-37
 Evidence NMR Reference
       Region 1-37 disorder
Seq 1-37 Monomer :
 Evidence NMR 1hn3 A Reference
       Region 1hn3 A 1-37 order
SeqProS verified 1-37 The structure in this region appeares under TFE. However, this region interacts with a disorder region (210-304) in MDM2 (IID00163) by forming a beta-sheet.(PubMed=11718560) :
       Region 1hn3 A 1-37 order
       Region 1-37 disorder
 
Prediction
NeProc
Disorder 32-37,44-138,166-169
Order 1-31,38-43,139-165
ProS 32-37,44-50,62-71,79-108,116-138,166-169
AlphaFold
Disorder 1-14,16-16,20-43,49-50,52-141,158-169
Order 15-15,17-19,44-48,51-51,142-157
Pfam Hmmer
PF07392 4-54 7.3e-28
SEG 70-76 ,105-121 ,143-164
Function
Function in SwissProt
Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination (By similarity). Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development. Isoform smARF may be involved in regulation of autophagy and caspase-independent cell death; the short-lived mitochondrial isoform is stabilized by C1QBP.