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IID50037
UniprotQ9Z2X2
Protein26S proteasome non-ATPase regulatory subunit 10
GenePsmd10
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
231
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-231 Hetero dimer : P54775
 Evidence X-RAY 3aji A Reference
       Region 3aji A 1-2 disorder
       Region 3aji A 3-231 order
 Evidence X-RAY 3aji C Reference
       Region 3aji C 1-2 disorder
       Region 3aji C 3-231 order
Seq 1-231 Hetero dimer : Q63570
 Evidence X-RAY 2dwz A Reference
       Region 2dwz A 1-3 disorder
       Region 2dwz A 4-229 order
       Region 2dwz A 230-231 disorder
 Evidence X-RAY 2dwz C Reference
       Region 2dwz C 1-3 disorder
       Region 2dwz C 4-229 order
       Region 2dwz C 230-231 disorder
Seq 1-231 Hetero dimer : IID00236Complex
 Evidence X-RAY 2dvw A Reference
       Region 2dvw A 1-2 disorder
       Region 2dvw A 3-231 order
 
Prediction
NeProc
Disorder 1-2
Order 3-231
ProS 1-2
AlphaFold
Disorder 1-3
Order 4-231
Pfam Hmmer
PF00023 39-71 2.9e-09
PF00023 72-104 4.5e-08
PF00023 105-137 1.2e-10
PF00023 138-170 0.00016
PF00023 171-203 3.8e-07
Function
Function in SwissProt
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module (By similarity). Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.
Acts as an oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export (By similarity).