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IID50042
 UniprotP23615
ProteinTranscription elongation factor SPT6
GeneSPT6
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1451
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 235-1451 Monomer :
 Evidence X-RAY 3psi A Reference
       Region 3psi A 239-311 disorder
       Region 3psi A 312-455 order
       Region 3psi A 456-463 disorder
       Region 3psi A 464-489 order
       Region 3psi A 490-508 disorder
       Region 3psi A 509-552 order
       Region 3psi A 553-566 disorder
       Region 3psi A 567-649 order
       Region 3psi A 650-652 disorder
       Region 3psi A 653-1001 order
       Region 3psi A 1002-1013 disorder
       Region 3psi A 1014-1210 order
       Region 3psi A 1211-1451 disorder
 Evidence X-RAY 3psf A Reference
       Region 3psf A 235-297 disorder
       Region 3psf A 298-455 order
       Region 3psf A 456-463 disorder
       Region 3psf A 464-484 order
       Region 3psf A 485-500 disorder
       Region 3psf A 501-561 order
       Region 3psf A 562-566 disorder
       Region 3psf A 567-1002 order
       Region 3psf A 1003-1008 disorder
       Region 3psf A 1009-1128 order
       Region 3psf A 1129-1218 disorder
       Region 3psf A 1219-1248 order
       Region 3psf A 1249-1259 disorder
Seq 239-263 Hetero dimer : IID50050Complex
 Evidence X-RAY 3oak C Reference
       Region 3oak C 239-263 order
 Evidence X-RAY 3oak D Reference
       Region 3oak D 239-263 order
Seq 1247-1451 Hetero dimer : P04050
 Evidence X-RAY 5vkl A Reference
       Region 5vkl A 1247-1249 disorder
       Region 5vkl A 1250-1451 order
Seq 1247-1451 Hetero dimer : P04050
 Evidence X-RAY 5vko A Reference
       Region 5vko A 1247-1249 disorder
       Region 5vko A 1250-1450 order
       Region 5vko A 1451-1451 disorder
Seq 1247-1451 Monomer :
 Evidence X-RAY 3psk D Reference
       Region 3psk D 1247-1251 disorder
       Region 3psk D 1252-1374 order
       Region 3psk D 1375-1378 disorder
       Region 3psk D 1379-1438 order
       Region 3psk D 1439-1451 disorder
 Evidence X-RAY 3psk C Reference
       Region 3psk C 1247-1251 disorder
       Region 3psk C 1252-1436 order
       Region 3psk C 1437-1451 disorder
 Evidence X-RAY 3psk B Reference
       Region 3psk B 1247-1440 order
       Region 3psk B 1441-1451 disorder
 Evidence X-RAY 3psk A Reference
       Region 3psk A 1247-1440 order
       Region 3psk A 1441-1451 disorder
 Evidence X-RAY 3psj A Reference
       Region 3psj A 1247-1251 disorder
       Region 3psj A 1252-1440 order
       Region 3psj A 1441-1451 disorder
 Evidence NMR 2l3t A Reference
       Region 2l3t A 1250-1440 order
       Region 2l3t A 1250-1250 high_rmsd
SeqProS verified 239-263 Hetero dimer : IID50050Complex
       Region 3oak C 239-263 order
       Region 3oak D 239-263 order
       Region 3psi A 239-311 disorder
Seqphosphorylation
    155-155 Phosphoserine
    206-206 Phosphoserine
    94-94 Phosphoserine
    134-134 Phosphoserine
    136-136 Phosphoserine
    148-148 Phosphoserine
    295-295 Phosphoserine
 
Prediction
NeProc
Disorder 1-255,294-294,488-497,1442-1451
Order 256-293,295-487,498-1004,1011-1441
ProS 6-12,31-37,50-64,82-110,117-126,145-154,167-175,194-205,211-219,233-255,488-493
AlphaFold
Disorder 1-95,98-98,104-214,216-216,218-300,455-462,490-500,1003-1011,1211-1218,1247-1251,1441-1451
Order 96-97,99-103,215-215,217-217,301-454,463-489,501-1002,1012-1210,1219-1246,1252-1440
Pfam Hmmer
PF00017 1258-1339 1.9e-16
SEG 28-52 ,77-101 ,150-172 ,192-211 ,258-283
Function
Function in SwissProt
Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.