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IID50046
 UniprotP50481
ProteinLIM/homeobox protein Lhx3
GeneLhx3
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
400
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 28-153 Homo dimer : IID50047Complex
 Evidence X-RAY 2rgt A Reference
       Region 2rgt A 28-31 disorder
       Region 2rgt A 32-153 order
Seq 28-153 Monomer : IID50047Complex
 Evidence X-RAY 2rgt B Reference
       Region 2rgt B 28-152 order
       Region 2rgt B 153-153 disorder
Seq 28-153 Monomer : IID50049Complex
 Evidence NMR 2jtn A Reference
       Region 2jtn A 28-153 order
Seqphosphorylation
    74-74 Phosphoserine
    230-230 Phosphotyrosine
    237-237 Phosphoserine
    241-241 Phosphoserine
 
Prediction
NeProc
Disorder 1-29,152-400
Order 30-151
ProS 1-14,152-218,249-278,316-321,341-349,377-400
AlphaFold
Disorder 1-29,160-162,225-231,233-400
Order 30-159,163-224,232-232
Pfam Hmmer
PF00412 34-90 7.2e-21
PF00412 93-153 4.4e-24
PF00046 161-217 8.3e-27
SEG 235-247 ,321-340 ,351-360
Function
Function in SwissProt
Required for the establishment of the specialized cells of the pituitary gland and the nervous system (By similarity). Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1. Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with Pou1f1/Pit-1.