Search Keyword:


Search option:


IID50049
 UniprotP70662
ProteinLIM domain-binding protein 1
GeneLdb1
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
411
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 331-375 Monomer : IID50046Complex
 Evidence NMR 2jtn A Reference
       Region 2jtn A 331-335 disorder
       Region 2jtn A 331-375 order
       Region 2jtn A 331-335 high_rmsd
       Region 2jtn A 336-369 order
       Region 2jtn A 370-375 disorder
       Region 2jtn A 370-375 high_rmsd
Seq 336-348 Hetero dimer : IID50040Complex,IID50043Complex
 Evidence NMR 2l6y B Reference
       Region 2l6y B 336-348 order
Seq 336-348 Hetero trimer : IID50040Complex,IID50043Complex
 Evidence NMR 2l6z C Reference
       Region 2l6z C 336-348 order
Seq 336-366 Monomer : IID50047Complex
 Evidence X-RAY 4jcj B Reference
       Region 4jcj B 336-336 disorder
       Region 4jcj B 337-346 order
       Region 4jcj B 347-350 disorder
       Region 4jcj B 351-364 order
       Region 4jcj B 365-366 disorder
Seq 336-366 Monomer : IID50047Complex
 Evidence X-RAY 4jcj A Reference
       Region 4jcj A 336-346 order
       Region 4jcj A 347-351 disorder
       Region 4jcj A 352-363 order
       Region 4jcj A 364-366 disorder
Seq 336-366 Monomer : IID50047Complex
 Evidence X-RAY 4jcj C Reference
       Region 4jcj C 336-347 order
       Region 4jcj C 348-350 disorder
       Region 4jcj C 351-364 order
       Region 4jcj C 365-366 disorder
Seqdisorder 336-374
 Evidence CD Reference
       Region 336-374 disorder
Seq 336-375 Monomer : IID50048Complex
 Evidence NMR 1m3v A Reference
       Region 1m3v A 336-353 disorder
       Region 1m3v A 336-375 order
       Region 1m3v A 336-353 high_rmsd
       Region 1m3v A 354-363 order
       Region 1m3v A 364-375 disorder
       Region 1m3v A 364-375 high_rmsd
Seq 336-375 Monomer : IID50043Complex
 Evidence NMR 2lxd A Reference
       Region 2lxd A 336-345 order
       Region 2lxd A 345-375 high_rmsd
       Region 2lxd A 346-375 disorder
Seq 336-375 Monomer : IID50043Complex
 Evidence NMR 1j2o A Reference
       Region 1j2o A 336-356 disorder
       Region 1j2o A 336-375 order
       Region 1j2o A 336-356 high_rmsd
       Region 1j2o A 357-363 order
       Region 1j2o A 364-375 disorder
       Region 1j2o A 364-375 high_rmsd
Seq 336-375 Monomer : IID50048Complex
 Evidence X-RAY 1rut X Reference
       Region 1rut X 336-363 order
       Region 1rut X 364-375 disorder
SeqProS verified 336-348 Hetero trimer : IID50040Complex,IID50043Complex
       Region 2l6z C 336-348 order
       Region 336-374 disorder
SeqProS verified 336-348 Hetero dimer : IID50040Complex,IID50043Complex
       Region 2l6y B 336-348 order
       Region 336-374 disorder
SeqProS verified 336-363 : IID50048Complex
       Region 1rut X 336-363 order
       Region 336-374 disorder
SeqProS verified 336-347,351-364 : IID50047Complex
       Region 4jcj B 337-346 order
       Region 4jcj B 351-364 order
       Region 336-374 disorder
SeqProS verified 336-347,351-364 : IID50047Complex
       Region 4jcj A 336-346 order
       Region 4jcj A 352-363 order
       Region 336-374 disorder
SeqProS verified 336-347,351-364 : IID50047Complex
       Region 4jcj C 336-347 order
       Region 4jcj C 351-364 order
       Region 336-374 disorder
SeqProS verified 336-369 : IID50046Complex
       Region 2jtn A 336-369 order
       Region 336-374 disorder
SeqProS verified 337-345 : IID50043Complex
       Region 2lxd A 336-345 order
       Region 336-374 disorder
SeqProS verified 354-363 : IID50048Complex
       Region 1m3v A 354-363 order
       Region 336-374 disorder
SeqProS verified 357-363 : IID50043Complex
       Region 1j2o A 357-363 order
       Region 336-374 disorder
Seqphosphorylation
    302-302 Phosphoserine
    265-265 Phosphoserine
    61-61 Phosphothreonine
Seqacetylation
    2-2 N-acetylserine
 
Prediction
NeProc
Disorder 1-62,222-236,269-411
Order 63-215,237-268
ProS 1-7,228-236,269-282
AlphaFold
Disorder 1-64,285-411
Order 65-284
Pfam Hmmer
PF01803 37-411 9.1e-299
SEG 300-323 ,391-404
Function
Function in SwissProt
Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state.