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IID50055
 UniprotQ8K4J6
ProteinMKL/myocardin-like protein 1
GeneMrtfa
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
964
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 16-41 Hetero tetramer : IID50082Complex
 Evidence X-RAY 2v51 E Reference
       Region 2v51 E 16-40 order
       Region 2v51 E 41-41 disorder
 Evidence X-RAY 2v51 F Reference
       Region 2v51 F 16-40 order
       Region 2v51 F 41-41 disorder
Seq 16-142 Hetero tetramer : IID50082Complex
 Evidence X-RAY 2yje M Reference
       Region 2yje M 16-63 order
       Region 2yje M 64-142 disorder
Seq 16-142 Hetero hexamer : IID50082Complex
 Evidence X-RAY 2yjf M Reference
       Region 2yjf M 16-126 order
       Region 2yjf M 127-142 disorder
Seqdisorder 16-142
 Evidence CD Reference
       Region 16-142 disorder
Seq 54-85 Hetero dimer : IID50082Complex
 Evidence X-RAY 2v52 M Reference
       Region 2v52 M 54-83 order
       Region 2v52 M 84-85 disorder
SeqProS verified 16-40 This region (54-83) is ordered in the complex with monomeric actin. Hetero tetramer : IID50082Complex
       Region 2v51 E 16-40 order
       Region 2v51 F 16-40 order
       Region 16-142 disorder
SeqProS verified 16-63 This region (16-63) is ordered in the complex with trimeric actin. Hetero tetramer : IID50082Complex
       Region 2yje M 16-63 order
       Region 16-142 disorder
SeqProS verified 16-126 This region (16-126) is ordered in the complex with pentameric actin. Hetero hexamer : IID50082Complex
       Region 2yjf M 16-126 order
       Region 16-142 disorder
SeqProS verified 54-83 This region (16-40) is ordered in the complex with monomeric actin. Hetero dimer : IID50082Complex
       Region 2v52 M 54-83 order
       Region 16-142 disorder
Seqphosphorylation
    842-842 Phosphothreonine
    892-892 Phosphoserine
    351-351 Phosphoserine
    840-840 Phosphoserine
    349-349 Phosphoserine
    191-191 Phosphoserine
    174-174 Phosphoserine
    159-159 Phosphoserine
    41-41 Phosphoserine
    530-530 Phosphoserine
    355-355 Phosphoserine
    358-358 Phosphoserine
    360-360 Phosphothreonine
    371-371 Phosphoserine
    423-423 Phosphoserine
    484-484 Phosphoserine
    485-485 Phosphothreonine
    487-487 Phosphoserine
    488-488 Phosphothreonine
    492-492 Phosphoserine
    494-494 Phosphothreonine
    496-496 Phosphoserine
    520-520 Phosphoserine
    352-352 Phosphothreonine
    544-544 Phosphoserine
    548-548 Phosphoserine
    605-605 Phosphoserine
    606-606 Phosphoserine
    651-651 Phosphoserine
    687-687 Phosphoserine
    718-718 Phosphoserine
    724-724 Phosphoserine
    728-728 Phosphoserine
    810-810 Phosphoserine
    822-822 Phosphothreonine
    826-826 Phosphoserine
 
Prediction
NeProc
Disorder 1-14,25-559,599-951,961-964
Order 15-24,560-598,952-960
ProS 1-14,25-37,48-65,70-81,96-126,132-140,153-160,394-401,773-776,781-787,844-848,873-898,910-927,944-951,961-964
AlphaFold
Disorder 1-4,129-271,273-273,275-276,278-291,318-379,423-557,597-692,702-777,797-871,882-964
Order 5-128,272-272,274-274,277-277,292-317,380-422,558-596,693-701,778-796,872-881
Pfam Hmmer
PF02755 59-84 0.0003
PF02755 103-128 0.00083
PF02037 385-419 9.3e-14
SEG 146-159 ,209-228 ,259-272 ,298-320 ,340-365 ,424-433 ,483-496 ,578-600 ,670-679 ,714-735
Function
Function in SwissProt
Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:12019265, PubMed:12732141, PubMed:17588931, PubMed:19350017, PubMed:24732378). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics (PubMed:24732378). MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex (PubMed:12732141, PubMed:17588931). Activity is also regulated by filamentous actin (F-actin) in the nucleus (PubMed:23558171, PubMed:25759381).