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IID50059
 UniprotO35615
ProteinZinc finger protein ZFPM1
GeneZfpm1
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
995
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 100-226 Monomer :
 Evidence NMR 2mpl A Reference
       Region 2mpl A 100-226 order
       Region 2mpl A 141-152 high_rmsd
       Region 2mpl A 207-226 high_rmsd
Seq 328-360 Monomer :
 Evidence NMR 1srk A Reference
       Region 1srk A 328-360 order
       Region 1srk A 359-360 high_rmsd
Seqphosphorylation
    927-927 Phosphoserine
    925-925 Phosphoserine
    822-822 Phosphoserine
    803-803 Phosphoserine
    684-684 Phosphoserine
    500-500 Phosphoserine
    651-651 Phosphoserine
    497-497 Phosphoserine
    397-397 Phosphoserine
    286-286 Phosphoserine
    143-143 Phosphoserine
    99-99 Phosphoserine
 
Prediction
NeProc
Disorder 1-152,207-240,284-314,384-586,592-602,608-960
Order 153-206,241-283,315-383,587-591,603-607,961-995
ProS 5-24,99-140,223-240,284-314,384-431,440-452,466-486,501-572,581-586,592-602,608-629,649-662,668-679,689-722,753-766,808-817,833-864,869-876,885-890
AlphaFold
Disorder 1-102,113-113,140-152,160-160,207-234,242-242,244-253,280-302,358-358,389-550,552-552,567-567,569-589,614-692,720-835,861-884,892-962,987-995
Order 103-112,114-139,153-159,161-206,235-241,243-243,254-279,303-357,359-388,551-551,553-566,568-568,590-613,693-719,836-860,885-891,963-986
Pfam Hmmer
PF00096 303-327 0.00085
SEG 32-72 ,86-94 ,508-525 ,570-578 ,626-663 ,725-755 ,761-779 ,785-806 ,823-834 ,948-961
Function
Function in SwissProt
Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.