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IID50060
 UniprotO35867
ProteinNeurabin-1
GenePpp1r9a
OrganismRattus norvegicus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1095
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 426-592 Hetero trimer : IID00311Complex
 Evidence X-RAY 3hvq D Reference
       Region 3hvq D 426-434 disorder
       Region 3hvq D 435-499 order
       Region 3hvq D 500-592 disorder
 Evidence X-RAY 3hvq C Reference
       Region 3hvq C 426-435 disorder
       Region 3hvq C 436-592 order
Seq 502-592 Monomer :
 Evidence NMR 2fn5 A Reference
       Region 2fn5 A 502-592 order
Seq 986-1056 Monomer :
 Evidence NMR 2gle A Reference
       Region 2gle A 986-1056 order
SeqProS possible 435-499 The spinophilin PP1 binding domain (O35274, 76.6% identity) is disordered in the free state. Hetero trimer : IID00311Complex
       Region 3hvq C 436-592 order
       Region 3hvq D 435-499 order
Seqphosphorylation
    192-192 Phosphoserine
    312-312 Phosphothreonine
    338-338 Phosphoserine
    461-461 Phosphoserine; by PKA
    372-372 Phosphoserine
    841-841 Phosphoserine
    916-916 Phosphoserine
    929-929 Phosphoserine
    957-957 Phosphoserine
    958-958 Phosphoserine
    961-961 Phosphoserine
    975-975 Phosphoserine
 
Prediction
NeProc
Disorder 1-456,485-488,629-673,824-985,1095-1095
Order 457-484,489-628,674-823,986-1094
ProS 14-38,54-73,122-127,135-148,158-164,172-177,188-192,243-248,379-387,395-418,429-450,629-637,659-663,673-673,824-824,852-857,863-877,902-910,938-963,974-985
AlphaFold
Disorder 1-62,73-434,525-530,595-595,597-597,624-673,825-984,1085-1095
Order 63-72,435-524,531-594,596-596,598-623,674-824,985-1084
Pfam Hmmer
PF00595 505-590 1e-14
PF07647 986-1052 2.3e-19
SEG 310-321 ,608-620 ,784-798 ,830-834 ,1043-1055 ,1081-1093
Function
Function in SwissProt
Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1-alpha activity. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction.