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IID50064
 UniprotP05205
ProteinHeterochromatin protein 1
GeneSu(var)205
OrganismDrosophila melanogaster
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
206
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 17-76 Hetero dimer :
 Evidence X-RAY 5kog A Reference
       Region 5kog A 17-21 disorder
       Region 5kog A 22-74 order
       Region 5kog A 75-76 disorder
Seq 17-76 Hetero dimer : IID00062Complex
 Evidence X-RAY 1q3l A Reference
       Region 1q3l A 17-22 disorder
       Region 1q3l A 23-74 order
       Region 1q3l A 75-76 disorder
Seq 17-76 Hetero dimer : P02299
 Evidence X-RAY 1kne A Reference
       Region 1kne A 17-22 disorder
       Region 1kne A 23-74 order
       Region 1kne A 75-76 disorder
 Evidence X-RAY 1kna A Reference
       Region 1kna A 17-22 disorder
       Region 1kna A 23-74 order
       Region 1kna A 75-76 disorder
Seq 17-76 Hetero dimer :
 Evidence X-RAY 6at0 A Reference
       Region 6at0 A 17-21 disorder
       Region 6at0 A 22-74 order
       Region 6at0 A 75-76 disorder
Seq 17-76 Hetero dimer :
 Evidence X-RAY 6asz A Reference
       Region 6asz A 17-21 disorder
       Region 6asz A 22-74 order
       Region 6asz A 75-76 disorder
Seq 131-206 Homo dimer :
 Evidence X-RAY 3p7j B Reference
       Region 3p7j B 131-140 disorder
       Region 3p7j B 141-201 order
       Region 3p7j B 202-206 disorder
 Evidence X-RAY 3p7j A Reference
       Region 3p7j A 131-140 disorder
       Region 3p7j A 141-199 order
       Region 3p7j A 200-206 disorder
Seqphosphorylation
    11-11 Phosphoserine
    15-15 Phosphoserine
    102-102 Phosphoserine
    103-103 Phosphoserine
    113-113 Phosphoserine
    127-127 Phosphothreonine
    134-134 Phosphothreonine
    128-128 Phosphothreonine
 
Prediction
NeProc
Disorder 1-24,78-136
Order 25-77,137-206
ProS 24-24,78-136
AlphaFold
Disorder 1-21,83-139,202-206
Order 22-82,140-201
Pfam Hmmer
PF00385 24-73 1.7e-21
PF01393 145-202 3.5e-34
SEG 9-31 ,49-60 ,100-115
Function
Function in SwissProt
Structural component of heterochromatin, involved in gene repression and the modification of position-effect-variegation. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression.