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IID50067
 UniprotP06701
ProteinRegulatory protein SIR3
GeneSIR3
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
978
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-213 Hetero decamer : IID50135Complex,IID50139Complex,IID50145Complex,IID50147Complex
 Evidence X-RAY 3tu4 L Reference
       Region 3tu4 L 1-1 disorder
       Region 3tu4 L 2-213 order
 Evidence X-RAY 3tu4 K Reference
       Region 3tu4 K 1-1 disorder
       Region 3tu4 K 2-213 order
Seq 1-219 Homo dimer :
 Evidence X-RAY 2fvu B Reference
       Region 2fvu B 1-17 order
       Region 2fvu B 18-36 disorder
       Region 2fvu B 37-76 order
       Region 2fvu B 77-82 disorder
       Region 2fvu B 83-213 order
       Region 2fvu B 214-219 disorder
 Evidence X-RAY 2fvu A Reference
       Region 2fvu A 1-17 order
       Region 2fvu A 18-37 disorder
       Region 2fvu A 38-76 order
       Region 2fvu A 77-82 disorder
       Region 2fvu A 83-213 order
       Region 2fvu A 214-219 disorder
Seq 1-229 Monomer :
 Evidence X-RAY 4kul A Reference
       Region 4kul A 2-2 order
       Region 4kul A 3-7 disorder
       Region 4kul A 8-24 order
       Region 4kul A 25-35 disorder
       Region 4kul A 36-77 order
       Region 4kul A 78-80 disorder
       Region 4kul A 81-214 order
       Region 4kul A 215-219 disorder
 Evidence X-RAY 4kui A Reference
       Region 4kui A 2-24 order
       Region 4kui A 25-36 disorder
       Region 4kui A 37-215 order
       Region 4kui A 216-219 disorder
 Evidence X-RAY 2fl7 A Reference
       Region 2fl7 A 1-7 disorder
       Region 2fl7 A 8-23 order
       Region 2fl7 A 24-36 disorder
       Region 2fl7 A 37-76 order
       Region 2fl7 A 77-81 disorder
       Region 2fl7 A 82-158 order
       Region 2fl7 A 159-165 disorder
       Region 2fl7 A 166-215 order
       Region 2fl7 A 216-229 disorder
Seq 2-219 Hetero decamer : IID50137Complex,IID50143Complex,IID50196Complex,P02309
 Evidence X-RAY 4kud L Reference
       Region 4kud L 2-214 order
       Region 4kud L 215-219 disorder
 Evidence X-RAY 4kud K Reference
       Region 4kud K 2-214 order
       Region 4kud K 215-219 disorder
Seq 2-229 Hetero decamer : IID50135Complex,IID50145Complex,IID50147Complex
 Evidence X-RAY 4ld9 L Reference
       Region 4ld9 L 2-29 order
       Region 4ld9 L 30-36 disorder
       Region 4ld9 L 37-213 order
       Region 4ld9 L 214-229 disorder
 Evidence X-RAY 4ld9 K Reference
       Region 4ld9 K 2-30 order
       Region 4ld9 K 31-33 disorder
       Region 4ld9 K 34-163 order
       Region 4ld9 K 164-164 disorder
       Region 4ld9 K 165-215 order
       Region 4ld9 K 216-229 disorder
Seq 2-382 Hetero decamer : IID50136Complex,IID50137Complex,IID50143Complex,P02309
 Evidence X-RAY 4jjn L Reference
       Region 4jjn L 2-3 disorder
       Region 4jjn L 4-23 order
       Region 4jjn L 24-27 disorder
       Region 4jjn L 28-218 order
       Region 4jjn L 219-382 disorder
 Evidence X-RAY 4jjn K Reference
       Region 4jjn K 2-2 order
       Region 4jjn K 3-5 disorder
       Region 4jjn K 6-19 order
       Region 4jjn K 20-21 disorder
       Region 4jjn K 22-33 order
       Region 4jjn K 34-36 disorder
       Region 4jjn K 37-214 order
       Region 4jjn K 215-382 disorder
Seq 456-481 Hetero trimer : IID50071Complex
 Evidence X-RAY 3owt C Reference
       Region 3owt C 456-460 disorder
       Region 3owt C 461-480 order
       Region 3owt C 481-481 disorder
Seq 530-845 Monomer :
 Evidence X-RAY 3te6 B Reference
       Region 3te6 B 530-617 order
       Region 3te6 B 618-620 disorder
       Region 3te6 B 621-634 order
       Region 3te6 B 635-636 disorder
       Region 3te6 B 637-760 order
       Region 3te6 B 761-768 disorder
       Region 3te6 B 769-844 order
       Region 3te6 B 845-845 disorder
 Evidence X-RAY 3te6 A Reference
       Region 3te6 A 530-618 order
       Region 3te6 A 619-620 disorder
       Region 3te6 A 621-636 order
       Region 3te6 A 637-638 disorder
       Region 3te6 A 639-760 order
       Region 3te6 A 761-768 disorder
       Region 3te6 A 769-844 order
       Region 3te6 A 845-845 disorder
Seq 840-978 Homo dimer :
 Evidence X-RAY 3zco A Reference
       Region 3zco A 840-848 disorder
       Region 3zco A 849-975 order
       Region 3zco A 976-978 disorder
SeqProS verified 24-33,77-81 Hetero decamer : IID50135Complex,IID50145Complex,IID50147Complex
       Region 4ld9 K 2-30 order
       Region 4ld9 L 2-29 order
       Region 4ld9 K 34-163 order
       Region 4ld9 L 37-213 order
       Region 2fvu A 18-37 disorder
       Region 2fvu A 77-82 disorder
SeqProS verified 24-33,77-81 Hetero decamer : IID50135Complex,IID50139Complex,IID50145Complex,IID50147Complex
       Region 3tu4 K 2-213 order
       Region 3tu4 L 2-213 order
       Region 2fvu A 18-37 disorder
       Region 2fvu A 77-82 disorder
SeqProS verified 24-33,77-81 Hetero decamer : IID50136Complex,IID50137Complex,IID50143Complex,P02309
       Region 4jjn K 22-33 order
       Region 4jjn L 28-218 order
       Region 4jjn K 37-214 order
       Region 2fvu A 18-37 disorder
       Region 2fvu A 77-82 disorder
SeqProS verified 24-33,77-81 Hetero decamer : IID50137Complex,IID50143Complex,IID50196Complex,P02309
       Region 4kud K 2-214 order
       Region 4kud L 2-214 order
       Region 2fvu A 18-37 disorder
       Region 2fvu A 77-82 disorder
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-7,13-36,205-522,752-769,820-827
Order 8-12,37-161,167-204,523-751,770-818,832-978
ProS 1-7,13-25,205-212,221-226,266-271,278-285,306-323,328-393
AlphaFold
Disorder 1-9,23-36,215-504,507-507,516-524,526-538,542-551,580-583,700-702,704-704,708-708,711-711,751-771,821-830,847-851,874-878,898-899,910-923,946-951,959-961,964-965,967-968,971-971,973-978
Order 10-22,37-214,505-506,508-515,525-525,539-541,552-579,584-699,703-703,705-707,709-710,712-750,772-820,831-846,852-873,879-897,900-909,924-945,952-958,962-963,966-966,969-970,972-972
Pfam Hmmer
PF01426 48-188 1.1e-25
SEG 280-300 ,375-388 ,772-784 ,931-947
Function
Function in SwissProt
The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.