IID50067
Uniprot P06701 Protein Regulatory protein SIR3 Gene SIR3 Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Sequence LLPS
Network
xml
rdf
Structure
atLeast majority ProS Experiment
:order disorder conflict PDB cluster ProS Pfam Domain SEG978
order/disorder by at least rule
disorder by at least rule
order/disorder by majority rule
Seq 1-213 Hetero decamer : IID50135 Complex ,
IID50139 Complex ,
IID50145 Complex ,
IID50147 Complex
Region 3tu4 L 1-1 disorder
Region 3tu4 L 2-213 order
Region 3tu4 K 1-1 disorder
Region 3tu4 K 2-213 order
Region 2fvu B 18-36 disorder
Region 2fvu B 37-76 order
Region 2fvu B 77-82 disorder
Region 2fvu B 83-213 order
Region 2fvu B 214-219 disorder
Region 2fvu A 18-37 disorder
Region 2fvu A 38-76 order
Region 2fvu A 77-82 disorder
Region 2fvu A 83-213 order
Region 2fvu A 214-219 disorder
Region 4kul A 3-7 disorder
Region 4kul A 25-35 disorder
Region 4kul A 36-77 order
Region 4kul A 78-80 disorder
Region 4kul A 81-214 order
Region 4kul A 215-219 disorder
Region 4kui A 25-36 disorder
Region 4kui A 37-215 order
Region 4kui A 216-219 disorder
Region 2fl7 A 1-7 disorder
Region 2fl7 A 24-36 disorder
Region 2fl7 A 37-76 order
Region 2fl7 A 77-81 disorder
Region 2fl7 A 82-158 order
Region 2fl7 A 159-165 disorder
Region 2fl7 A 166-215 order
Region 2fl7 A 216-229 disorder
Seq 2-219 Hetero decamer : IID50137 Complex ,
IID50143 Complex ,
IID50196 Complex ,
P02309
Region 4kud L 2-214 order
Region 4kud L 215-219 disorder
Region 4kud K 2-214 order
Region 4kud K 215-219 disorder
Seq 2-229 Hetero decamer : IID50135 Complex ,
IID50145 Complex ,
IID50147 Complex
Region 4ld9 L 30-36 disorder
Region 4ld9 L 37-213 order
Region 4ld9 L 214-229 disorder
Region 4ld9 K 31-33 disorder
Region 4ld9 K 34-163 order
Region 4ld9 K 164-164 disorder
Region 4ld9 K 165-215 order
Region 4ld9 K 216-229 disorder
Seq 2-382 Hetero decamer : IID50136 Complex ,
IID50137 Complex ,
IID50143 Complex ,
P02309
Region 4jjn L 2-3 disorder
Region 4jjn L 24-27 disorder
Region 4jjn L 28-218 order
Region 4jjn L 219-382 disorder
Region 4jjn K 3-5 disorder
Region 4jjn K 20-21 disorder
Region 4jjn K 22-33 order
Region 4jjn K 34-36 disorder
Region 4jjn K 37-214 order
Region 4jjn K 215-382 disorder
Seq 456-481 Hetero trimer : IID50071 Complex
Region 3owt C 456-460 disorder
Region 3owt C 461-480 order
Region 3owt C 481-481 disorder
Region 3te6 B 530-617 order
Region 3te6 B 618-620 disorder
Region 3te6 B 621-634 order
Region 3te6 B 635-636 disorder
Region 3te6 B 637-760 order
Region 3te6 B 761-768 disorder
Region 3te6 B 769-844 order
Region 3te6 B 845-845 disorder
Region 3te6 A 530-618 order
Region 3te6 A 619-620 disorder
Region 3te6 A 621-636 order
Region 3te6 A 637-638 disorder
Region 3te6 A 639-760 order
Region 3te6 A 761-768 disorder
Region 3te6 A 769-844 order
Region 3te6 A 845-845 disorder
Region 3zco A 840-848 disorder
Region 3zco A 849-975 order
Region 3zco A 976-978 disorder
Seq ProS verified 24-33,77-81 Hetero decamer : IID50135 Complex ,
IID50145 Complex ,
IID50147 Complex
Region 4ld9 K 34-163 order
Region 4ld9 L 37-213 order
Region 2fvu A 18-37 disorder
Region 2fvu A 77-82 disorder
Seq ProS verified 24-33,77-81 Hetero decamer : IID50135 Complex ,
IID50139 Complex ,
IID50145 Complex ,
IID50147 Complex
Region 3tu4 K 2-213 order
Region 3tu4 L 2-213 order
Region 2fvu A 18-37 disorder
Region 2fvu A 77-82 disorder
Seq ProS verified 24-33,77-81 Hetero decamer : IID50136 Complex ,
IID50137 Complex ,
IID50143 Complex ,
P02309
Region 4jjn K 22-33 order
Region 4jjn L 28-218 order
Region 4jjn K 37-214 order
Region 2fvu A 18-37 disorder
Region 2fvu A 77-82 disorder
Seq ProS verified 24-33,77-81 Hetero decamer : IID50137 Complex ,
IID50143 Complex ,
IID50196 Complex ,
P02309
Region 4kud K 2-214 order
Region 4kud L 2-214 order
Region 2fvu A 18-37 disorder
Region 2fvu A 77-82 disorder
Prediction
Function
Function in SwissProt
The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.
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