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IID50068
 UniprotP10279
ProteinMajor prion protein
GenePRNP
OrganismBos taurus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
264
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-30 Monomer :
 Evidence NMR 1skh A Reference
       Region 1skh A 1-30 order
       Region 1skh A 1-4 high_rmsd
       Region 1skh A 25-30 high_rmsd
Seqdisorder 1-30
 Evidence CD Reference
       Region 1-30 disorder
Seq 25-241 Monomer :
 Evidence NMR 1dx0 A Reference
       Region 1dx0 A 25-134 disorder
       Region 1dx0 A 135-238 order
       Region 1dx0 A 239-241 disorder
 Evidence NMR 1dwz A Reference
       Region 1dwz A 132-134 disorder
       Region 1dwz A 135-238 order
       Region 1dwz A 239-241 disorder
 Evidence NMR 1dwy A Reference
       Region 1dwy A 132-134 disorder
       Region 1dwy A 135-238 order
       Region 1dwy A 239-241 disorder
 Evidence NMR 1dx1 A Reference
       Region 1dx1 A 25-134 disorder
       Region 1dx1 A 135-238 order
       Region 1dx1 A 239-241 disorder
Seq 103-242 Hetero trimer :
 Evidence X-RAY 4yx2 A Reference
       Region 4yx2 A 103-135 disorder
       Region 4yx2 A 136-236 order
       Region 4yx2 A 237-242 disorder
Seq 107-115 Hetero trimer :
 Evidence X-RAY 2hh0 P Reference
       Region 2hh0 P 107-115 order
Seq 108-119 Homo dimer :
 Evidence NMR 2ru7 D Reference
       Region 2ru7 D 108-119 order
 Evidence NMR 2ru7 C Reference
       Region 2ru7 C 108-119 order
 Evidence NMR 2rsk D Reference
       Region 2rsk D 108-119 order
 Evidence NMR 2rsk C Reference
       Region 2rsk C 108-119 order
SeqProS verified 108-119 This region is ordered in the complex with RNA. Homo dimer :
       Region 2rsk C 108-119 order
       Region 2rsk D 108-119 order
       Region 2ru7 C 108-119 order
       Region 2ru7 D 108-119 order
       Region 1dx1 A 25-134 disorder
 
Prediction
NeProc
Disorder 1-4,25-115,264-264
Order 5-24,116-199,206-263
ProS 1-4,25-25,32-35,57-101,108-115,264-264
AlphaFold
Disorder 1-5,18-136,240-249,264-264
Order 6-17,137-239,250-263
Pfam Hmmer
PF00377 145-263 6e-71
SEG 53-110 ,123-138 ,194-212 ,248-263
Function
Function in SwissProt
Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).