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IID50069
UniprotP11632
ProteinNon-histone chromosomal protein 6A
GeneNHP6A
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
93
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-93 Monomer :
 Evidence NMR 1cg7 A Reference
       Region 1cg7 A 1-17 disorder
       Region 1cg7 A 1-17 high_rmsd
       Region 1cg7 A 18-93 order
 Evidence NMR 1j5n A Reference
       Region 1j5n A 1-9 disorder
       Region 1j5n A 1-10 high_rmsd
       Region 1j5n A 10-93 order
 Evidence NMR 1lwm A Reference
       Region 1lwm A 1-17 disorder
       Region 1lwm A 1-18 high_rmsd
       Region 1lwm A 18-93 order
SeqProS verified 10-17 This region is ordered in the DNA complex. :
       Region 1j5n A 10-93 order
       Region 1lwm A 1-17 disorder
 
Prediction
NeProc
Disorder 1-21,71-93
Order 22-70
ProS 16-21,71-93
AlphaFold
Disorder 1-22,92-93
Order 23-91
Pfam Hmmer
PF00505 21-89 2.8e-35
SEG 3-18
Function
Function in SwissProt
DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex. Required for transcriptional initiation fidelity of some but not all tRNA genes. Seems to be functionally redundant with NHP6B.