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IID50071
 UniprotP11938
ProteinDNA-binding protein RAP1
GeneRAP1
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
827
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 116-212 Monomer :
 Evidence NMR 2l42 A Reference
       Region 2l42 A 116-212 order
       Region 2l42 A 116-124 high_rmsd
       Region 2l42 A 212-212 high_rmsd
Seq 353-602 Monomer :
 Evidence X-RAY 3ukg A Reference
       Region 3ukg A 360-479 order
       Region 3ukg A 480-498 disorder
       Region 3ukg A 499-601 order
 Evidence X-RAY 1ign B Reference
       Region 1ign B 353-359 disorder
       Region 1ign B 360-481 order
       Region 1ign B 482-512 disorder
       Region 1ign B 513-564 order
       Region 1ign B 565-571 disorder
       Region 1ign B 572-578 order
       Region 1ign B 579-586 disorder
       Region 1ign B 587-594 order
       Region 1ign B 595-598 disorder
 Evidence X-RAY 1ign A Reference
       Region 1ign A 353-359 disorder
       Region 1ign A 360-481 order
       Region 1ign A 482-512 disorder
       Region 1ign A 513-564 order
       Region 1ign A 565-571 disorder
       Region 1ign A 572-578 order
       Region 1ign A 579-586 disorder
       Region 1ign A 587-594 order
       Region 1ign A 595-598 disorder
 Evidence X-RAY 4gfb A Reference
       Region 4gfb A 358-482 order
       Region 4gfb A 483-501 disorder
       Region 4gfb A 502-581 order
       Region 4gfb A 582-582 disorder
       Region 4gfb A 583-595 order
       Region 4gfb A 596-602 disorder
Seq 627-827 Hetero trimer : IID50224Complex
 Evidence X-RAY 4bj6 E Reference
       Region 4bj6 E 627-674 disorder
       Region 4bj6 E 675-825 order
       Region 4bj6 E 826-827 disorder
 Evidence X-RAY 4bj6 C Reference
       Region 4bj6 C 627-674 disorder
       Region 4bj6 C 675-825 order
       Region 4bj6 C 826-827 disorder
Seq 627-827 Hetero dimer : IID50206Complex
 Evidence X-RAY 4bjt B Reference
       Region 4bjt B 627-675 disorder
       Region 4bjt B 676-827 order
 Evidence X-RAY 4bjt A Reference
       Region 4bjt A 627-675 disorder
       Region 4bjt A 676-827 order
 Evidence X-RAY 4bjt C Reference
       Region 4bjt C 627-675 disorder
       Region 4bjt C 676-827 order
Seq 627-827 Hetero hexamer : IID50224Complex
 Evidence X-RAY 4bj5 E Reference
       Region 4bj5 E 627-674 disorder
       Region 4bj5 E 675-825 order
       Region 4bj5 E 826-827 disorder
 Evidence X-RAY 4bj5 C Reference
       Region 4bj5 C 627-674 disorder
       Region 4bj5 C 675-825 order
       Region 4bj5 C 826-827 disorder
Seq 672-827 Monomer :
 Evidence X-RAY 3cz6 B Reference
       Region 3cz6 B 672-673 disorder
       Region 3cz6 B 674-824 order
       Region 3cz6 B 825-827 disorder
 Evidence X-RAY 3cz6 A Reference
       Region 3cz6 A 672-673 disorder
       Region 3cz6 A 674-824 order
       Region 3cz6 A 825-827 disorder
Seq 672-827 Hetero trimer : IID50067Complex
 Evidence X-RAY 3owt B Reference
       Region 3owt B 672-675 disorder
       Region 3owt B 676-823 order
       Region 3owt B 824-827 disorder
 Evidence X-RAY 3owt A Reference
       Region 3owt A 672-676 disorder
       Region 3owt A 677-824 order
       Region 3owt A 825-827 disorder
Seqphosphorylation
    731-731 Phosphoserine
    486-486 Phosphothreonine
 
Prediction
NeProc
Disorder 1-122,219-357,471-523,543-729
Order 123-163,170-218,358-470,524-542,730-827
ProS 4-26,39-85,91-102,295-305,471-486,498-513,543-563,569-583,684-709,722-729
AlphaFold
Disorder 1-125,127-127,135-145,162-170,180-182,204-204,206-206,208-208,210-274,276-277,279-359,483-485,488-489,491-491,495-495,498-503,601-667,670-670,730-730,824-827
Order 126-126,128-134,146-161,171-179,183-203,205-205,207-207,209-209,275-275,278-278,360-482,486-487,490-490,492-494,496-497,504-600,668-669,671-729,731-823
Pfam Hmmer
PF00533 121-195 2.1e-06
PF00249 360-411 1e-08
SEG 60-84 ,108-119 ,225-242 ,270-285 ,310-325 ,612-630
Function
Function in SwissProt
Essential regulatory protein in yeast whose DNA-binding sites are found at three types of chromosomal elements: promoters, silencers, and telomeres. RAP1 is also involved in the regulation of telomere structure, where its binding sites are found within the terminal poly[C(1-3)A] sequences. The opposite regulatory functions of RAP1 are not intrinsic to its binding sites but, instead, result from interactions with different factors at promoters and silencers. RAP1 associates with SIR3 and SIR4 proteins to form a DNA-binding complex that initiates the repression at the HM loci and telomeres. May also target the binding of RIF1 and RIF2 to silencers and telomeres. Forms with GCR1 a transcriptional activation complex that is required for expression of glycolytic and ribosomal gene.