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IID50074
 UniprotP33242
ProteinSteroidogenic factor 1
GeneNr5a1
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
462
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 10-111 Monomer :
 Evidence NMR 2ff0 A Reference
       Region 2ff0 A 10-111 order
       Region 2ff0 A 107-111 high_rmsd
Seq 219-462 Hetero dimer : IID50230Complex
 Evidence X-RAY 1ymt A Reference
       Region 1ymt A 219-250 order
       Region 1ymt A 251-258 disorder
       Region 1ymt A 259-459 order
       Region 1ymt A 460-462 disorder
Seq 219-462 Hetero dimer : IID50038Complex
 Evidence X-RAY 3f7d A Reference
       Region 3f7d A 219-221 disorder
       Region 3f7d A 222-255 order
       Region 3f7d A 256-257 disorder
       Region 3f7d A 258-461 order
       Region 3f7d A 462-462 disorder
Seq 223-461 Hetero dimer : IID50220Complex
 Evidence X-RAY 1yp0 A Reference
       Region 1yp0 A 223-461 order
Seqphosphorylation
    203-203 Phosphoserine; by CDK7
Seqacetylation
    34-34 N6-acetyllysine
    38-38 N6-acetyllysine
    72-72 N6-acetyllysine
 
Prediction
NeProc
Disorder 83-260
Order 1-82,261-462
ProS 83-100,161-171,187-192,199-203,215-248
AlphaFold
Disorder 1-10,90-91,116-222,252-260,450-450,460-462
Order 11-89,92-115,223-251,261-449,451-459
Pfam Hmmer
PF00105 11-86 4.7e-53
PF00104 271-456 4.9e-47
SEG 124-142 ,195-222 ,225-238
Function
Function in SwissProt
Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity (By similarity). Transcription repressor of the Moloney leukemia virus long terminal repeat in undifferentiated murine embryonal carcinoma cells. Binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular phosphatidyl(3,4)bisphosphate, phosphatidyl(3,5)bisphosphate and phosphatidyl(3,4,5)triphosphate. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.