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IID50077
 UniprotP56273
ProteinE3 ubiquitin-protein ligase Mdm2
Genemdm2
OrganismXenopus laevis
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
473
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 13-119 Hetero tetramer : IID00015Complex
 Evidence X-RAY 1ycq A Reference
       Region 1ycq A 13-20 disorder
       Region 1ycq A 21-108 order
       Region 1ycq A 109-119 disorder
Seq 13-119 Monomer :
 Evidence NMR 1ttv A Reference
       Region 1ttv A 13-119 order
 Evidence X-RAY 4lwv C Reference
       Region 4lwv C 21-105 order
 Evidence X-RAY 4lwv B Reference
       Region 4lwv B 21-105 order
 Evidence X-RAY 4lwv A Reference
       Region 4lwv A 21-105 order
 Evidence X-RAY 4lwu A Reference
       Region 4lwu A 21-105 order
 Evidence X-RAY 4lwt A Reference
       Region 4lwt A 21-105 order
 Evidence X-RAY 4jsc B Reference
       Region 4jsc B 21-21 disorder
       Region 4jsc B 22-104 order
       Region 4jsc B 105-105 disorder
 Evidence X-RAY 4jsc A Reference
       Region 4jsc A 21-21 disorder
       Region 4jsc A 22-104 order
       Region 4jsc A 105-105 disorder
 Evidence X-RAY 4jrg B Reference
       Region 4jrg B 21-104 order
       Region 4jrg B 105-105 disorder
 Evidence X-RAY 4jrg A Reference
       Region 4jrg A 21-104 order
       Region 4jrg A 105-105 disorder
 Evidence X-RAY 4j7e A Reference
       Region 4j7e A 21-105 order
 Evidence X-RAY 4j7d A Reference
       Region 4j7d A 21-105 order
 Evidence X-RAY 4j74 A Reference
       Region 4j74 A 21-105 order
 Evidence X-RAY 4j3e A Reference
       Region 4j3e A 21-105 order
 Evidence X-RAY 4ipf A Reference
       Region 4ipf A 21-105 order
 
Prediction
NeProc
Disorder 1-18,114-285,333-415
Order 19-113,286-332,416-473
ProS 6-18,114-123,135-150,157-204,212-242,261-276,342-366,383-393
AlphaFold
Disorder 1-21,108-234,240-264,266-285,323-347,349-416
Order 22-107,235-239,265-265,286-322,348-348,417-473
Pfam Hmmer
PF02201 23-98 2.8e-23
PF00641 290-319 0.00011
SEG 29-34 ,204-216 ,400-411
Function
Function in SwissProt
E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome.
Biological Process
Diagram with PDB data
mdm2NMR Structure of a Complex Between MDM2 and a Small Molecule Inhibitor
See also
Diagram with PDB data
TP53/EP300Structural Basis for the Regulation of p53 Function by p300
TP53/CREBBPNMR Structure of CBP Bromodomain in complex with p53 peptide
TP53/SETD7Crystal structure of a ternary complex of the methyltransferase SET9 (also known as SET7/9) with a P53 peptide and SAH
TP53/SMYD2Structure of SMYD2 in complex with p53 and SAH
TP53/MDM2Crystal Structure of an MDM2/P53 Peptide Complex