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IID50078
 UniprotP60605
ProteinUbiquitin-conjugating enzyme E2 G2
GeneUbe2g2
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
165
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-165 Hetero trimer : IID00226Complex
 Evidence X-RAY 3fsh B Reference
       Region 3fsh B 1-95 order
       Region 3fsh B 96-107 disorder
       Region 3fsh B 108-165 order
 Evidence X-RAY 3fsh A Reference
       Region 3fsh A 1-95 order
       Region 3fsh A 96-107 disorder
       Region 3fsh A 108-165 order
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-5
Order 6-165
AlphaFold
Disorder 1-2
Order 3-165
Pfam Hmmer
PF00179 8-159 7e-83
Function
Function in SwissProt
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD). Required for sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its subsequent proteasomal degradation.