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IID50080
 UniprotP62152
ProteinCalmodulin
GeneCam
OrganismDrosophila melanogaster
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
149
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-149 Hetero dimer : P42212,Q29122
 Evidence X-RAY 4anj B Reference
       Region 4anj B 1-5 disorder
       Region 4anj B 6-27 order
       Region 4anj B 28-31 disorder
       Region 4anj B 32-76 order
       Region 4anj B 77-80 disorder
       Region 4anj B 81-111 order
       Region 4anj B 112-117 disorder
       Region 4anj B 118-147 order
       Region 4anj B 148-149 disorder
Seq 1-149 Hetero dimer : Q29122
 Evidence X-RAY 2x51 B Reference
       Region 2x51 B 1-3 disorder
       Region 2x51 B 4-149 order
 Evidence X-RAY 2vas B Reference
       Region 2vas B 1-4 disorder
       Region 2vas B 5-75 order
       Region 2vas B 76-78 disorder
       Region 2vas B 79-148 order
       Region 2vas B 149-149 disorder
 Evidence X-RAY 3l9i C Reference
       Region 3l9i C 1-3 disorder
       Region 3l9i C 4-148 order
       Region 3l9i C 149-149 disorder
 Evidence X-RAY 4dbq B Reference
       Region 4dbq B 1-1 disorder
       Region 4dbq B 2-149 order
 Evidence X-RAY 4dbp C Reference
       Region 4dbp C 1-3 disorder
       Region 4dbp C 4-73 order
       Region 4dbp C 74-80 disorder
       Region 4dbp C 81-148 order
       Region 4dbp C 149-149 disorder
 Evidence X-RAY 2bkh B Reference
       Region 2bkh B 2-3 disorder
       Region 2bkh B 4-73 order
       Region 2bkh B 74-81 disorder
       Region 2bkh B 82-148 order
Seq 1-149 Hetero trimer : Q29122
 Evidence X-RAY 3gn4 H Reference
       Region 3gn4 H 1-3 disorder
       Region 3gn4 H 4-148 order
       Region 3gn4 H 149-149 disorder
 Evidence X-RAY 3gn4 F Reference
       Region 3gn4 F 1-2 disorder
       Region 3gn4 F 3-148 order
       Region 3gn4 F 149-149 disorder
 Evidence X-RAY 3gn4 D Reference
       Region 3gn4 D 1-3 disorder
       Region 3gn4 D 4-148 order
       Region 3gn4 D 149-149 disorder
 Evidence X-RAY 3gn4 B Reference
       Region 3gn4 B 1-3 disorder
       Region 3gn4 B 4-148 order
       Region 3gn4 B 149-149 disorder
Seq 1-149 Hetero dimer : F1RQI7
 Evidence X-RAY 4pjj B Reference
       Region 4pjj B 1-2 disorder
       Region 4pjj B 3-148 order
       Region 4pjj B 149-149 disorder
Seq 2-149 Hetero dimer : IID50197Complex
 Evidence NMR 2bbn A Reference
       Region 2bbn A 2-149 order
       Region 2bbn A 2-4 high_rmsd
       Region 2bbn A 78-80 high_rmsd
       Region 2bbn A 148-149 high_rmsd
 Evidence NMR 2bbm A Reference
       Region 2bbm A 2-149 order
Seq 2-149 Monomer :
 Evidence X-RAY 4cln A Reference
       Region 4cln A 2-149 order
Seq 2-149 Hetero dimer : IID50054Complex
 Evidence X-RAY 1mxe B Reference
       Region 1mxe B 2-4 disorder
       Region 1mxe B 5-148 order
       Region 1mxe B 149-149 disorder
 Evidence X-RAY 1mxe A Reference
       Region 1mxe A 2-4 disorder
       Region 1mxe A 5-148 order
       Region 1mxe A 149-149 disorder
Seqacetylation
    2-2 N-acetylalanine
 
Prediction
NeProc
Disorder 1-2,147-149
Order 3-146
ProS 1-2
AlphaFold
Disorder 1-5,75-82,148-149
Order 6-74,83-147
Pfam Hmmer
PF00036 12-40 2.1e-09
PF00036 48-76 5.1e-09
PF00036 85-113 6.1e-10
PF00036 121-149 9.1e-10
Function
Function in SwissProt
Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+) (By similarity). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). In photoreceptor cells, light-induced Ca(2+) influx activates calmodulin, which in turn is likely to promote Crag activity in trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes (PubMed:23226104). Together with Akap200, regulates PKA activity and ethanol-induced sensitivity and tolerance (PubMed:10480937, PubMed:29444420).
Biological Process
See also
Diagram with PDB data
MYLK2/CALM1SOLUTION STRUCTURE OF A CALMODULIN-TARGET PEPTIDE COMPLEX BY MULTIDIMENSIONAL NMR
Camk1/CALM1Solution structure of Ca2+/calmodulin complexed with a peptide representing the calmodulin-binding domain of calmodulin kinase I