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IID50083
 UniprotP70218
ProteinMitogen-activated protein kinase kinase kinase kinase 1
GeneMap4k1
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
827
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 465-480 Hetero dimer : IID50062Complex
 Evidence X-RAY 1uti D Reference
       Region 1uti D 465-480 order
Seqphosphorylation
    403-403 Phosphoserine
    592-592 Phosphoserine
    419-419 Phosphoserine
    405-405 Phosphoserine
    375-375 Phosphoserine
    373-373 Phosphoserine
    354-354 Phosphothreonine; by autocatalysis
    175-175 Phosphothreonine; by autocatalysis
    171-171 Phosphoserine; by autocatalysis
    165-165 Phosphothreonine; by autocatalysis
 
Prediction
NeProc
Disorder 1-8,290-490,580-589,815-818
Order 9-289,491-579,590-814,819-827
ProS 1-8,290-300,308-343,351-382,389-404,411-428,437-455,466-480,589-589,815-818
AlphaFold
Disorder 1-6,25-28,54-62,157-175,184-191,294-313,321-336,343-490,580-602,623-624,700-712,714-714,749-749,783-783,802-804
Order 7-24,29-53,63-156,176-183,192-293,314-320,337-342,491-579,603-622,625-699,713-713,715-748,750-782,784-801,805-827
Pfam Hmmer
PF00069 17-274 1e-66
PF00780 507-813 5.9e-102
SEG 301-318 ,373-383 ,385-416 ,426-446 ,655-672
Function
Function in SwissProt
Serine/threonine-protein kinase, which may play a role in the response to environmental stress (By similarity). Appears to act upstream of the JUN N-terminal pathway (PubMed:9003777). May play a role in hematopoietic lineage decisions and growth regulation (PubMed:9003777). Able to autophosphorylate (PubMed:9003777). Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production (PubMed:11509653).