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IID50085
 UniprotQ03818
ProteinAutophagy protein 16
GeneATG16
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
150
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-46 Hetero trimer : IID50256Complex
 Evidence X-RAY 3w1s B Reference
       Region 3w1s B 1-21 disorder
       Region 3w1s B 22-46 order
Seq 1-46 Hetero dimer : IID50256Complex
 Evidence X-RAY 2dym H Reference
       Region 2dym H 1-22 disorder
       Region 2dym H 23-46 order
 Evidence X-RAY 2dym F Reference
       Region 2dym F 1-22 disorder
       Region 2dym F 23-46 order
 Evidence X-RAY 2dym D Reference
       Region 2dym D 1-22 disorder
       Region 2dym D 23-46 order
 Evidence X-RAY 2dym B Reference
       Region 2dym B 1-22 disorder
       Region 2dym B 23-46 order
Seq 1-57 Hetero dimer : IID50256Complex
 Evidence X-RAY 2dyo B Reference
       Region 2dyo B 1-21 disorder
       Region 2dyo B 22-57 order
Seq 1-150 Homo dimer :
 Evidence X-RAY 3a7p B Reference
       Region 3a7p B 1-57 disorder
       Region 3a7p B 58-133 order
       Region 3a7p B 134-150 disorder
 Evidence X-RAY 3a7p A Reference
       Region 3a7p A 1-54 disorder
       Region 3a7p A 55-142 order
       Region 3a7p A 143-150 disorder
Seq 50-123 Homo dimer :
 Evidence X-RAY 3a7o F Reference
       Region 3a7o F 50-60 disorder
       Region 3a7o F 61-118 order
       Region 3a7o F 119-123 disorder
 Evidence X-RAY 3a7o E Reference
       Region 3a7o E 50-59 disorder
       Region 3a7o E 60-119 order
       Region 3a7o E 120-123 disorder
 Evidence X-RAY 3a7o D Reference
       Region 3a7o D 50-58 disorder
       Region 3a7o D 59-116 order
       Region 3a7o D 117-123 disorder
 Evidence X-RAY 3a7o C Reference
       Region 3a7o C 50-59 disorder
       Region 3a7o C 60-112 order
       Region 3a7o C 113-123 disorder
 Evidence X-RAY 3a7o B Reference
       Region 3a7o B 50-60 disorder
       Region 3a7o B 61-114 order
       Region 3a7o B 115-123 disorder
 Evidence X-RAY 3a7o A Reference
       Region 3a7o A 50-59 disorder
       Region 3a7o A 60-118 order
       Region 3a7o A 119-123 disorder
SeqProS verified 22-46 Hetero trimer : IID50256Complex
       Region 3w1s B 22-46 order
       Region 3a7p B 1-57 disorder
SeqProS verified 22-57 Hetero dimer : IID50256Complex
       Region 2dyo B 22-57 order
       Region 3a7p B 1-57 disorder
SeqProS verified 23-46 Hetero dimer : IID50256Complex
       Region 2dym B 23-46 order
       Region 2dym D 23-46 order
       Region 2dym F 23-46 order
       Region 2dym H 23-46 order
       Region 3a7p B 1-57 disorder
 
Prediction
NeProc
Disorder 1-22,48-60,138-150
Order 23-47,61-137
ProS 1-7,19-22,138-150
AlphaFold
Disorder 1-22,45-58,149-150
Order 23-44,59-148
Pfam Hmmer
PF08614 24-144 4.2e-41
Function
Function in SwissProt
Stabilizes the ATG5-ATG12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The ATG5-ATG12/ATG16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS). Recruits also ATG3 to the PAS. Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress.