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IID50087
 UniprotQ09260
ProteinProtein lag-3
Genesel-8
OrganismCaenorhabditis elegans
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
490
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 49-132 Hetero trimer : IID50027Complex,IID50096Complex
 Evidence X-RAY 2fo1 D Reference
       Region 2fo1 D 49-51 disorder
       Region 2fo1 D 52-114 order
       Region 2fo1 D 115-132 disorder
 
Prediction
NeProc
Disorder 1-71,106-263,308-337,400-490
Order 72-105,264-307,338-399
ProS 1-23,41-71,112-118,132-148,165-169,187-193,200-204,218-228,236-241,257-263,320-325,404-428,454-467,478-490
AlphaFold
Disorder 1-58,125-158,161-185,187-189,191-273,275-339,398-415,418-418,439-439,442-490
Order 59-124,159-160,186-186,190-190,274-274,340-397,416-417,419-438,440-441
SEG 24-42 ,162-209 ,341-404 ,413-456
Function
Function in SwissProt
glp-1 and lin-12 Notch proteins promote signaling by recruiting lag-3 to target promoters, where it functions as a transcriptional activator, probably as part of a complex with a Notch intracellular domain (NICD) and the transcription regulator lag-1 (PubMed:10830967, PubMed:16530045). May regulate phosphatase lip-1 mRNA transcription downstream of glp-1 (PubMed:16319922).