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IID50091
UniprotQ62120
ProteinTyrosine-protein kinase JAK2
GeneJak2
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1129
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 810-820 Hetero dimer : IID50098Complex
 Evidence X-RAY 2hdx L Reference
       Region 2hdx L 810-818 order
       Region 2hdx L 819-820 disorder
 Evidence X-RAY 2hdx K Reference
       Region 2hdx K 810-811 disorder
       Region 2hdx K 812-818 order
       Region 2hdx K 819-820 disorder
 Evidence X-RAY 2hdx J Reference
       Region 2hdx J 810-811 disorder
       Region 2hdx J 812-818 order
       Region 2hdx J 819-820 disorder
 Evidence X-RAY 2hdx I Reference
       Region 2hdx I 810-811 disorder
       Region 2hdx I 812-818 order
       Region 2hdx I 819-820 disorder
 Evidence X-RAY 2hdx H Reference
       Region 2hdx H 810-811 disorder
       Region 2hdx H 812-818 order
       Region 2hdx H 819-820 disorder
 Evidence X-RAY 2hdx G Reference
       Region 2hdx G 810-818 order
       Region 2hdx G 819-820 disorder
Seq 836-1129 Hetero trimer : IID50193Complex
 Evidence X-RAY 4gl9 A Reference
       Region 4gl9 A 836-842 disorder
       Region 4gl9 A 843-919 order
       Region 4gl9 A 920-923 disorder
       Region 4gl9 A 924-1127 order
       Region 4gl9 A 1128-1129 disorder
Seq 836-1129 Hetero trimer : IID50193Complex
 Evidence X-RAY 4gl9 B Reference
       Region 4gl9 B 836-842 disorder
       Region 4gl9 B 843-919 order
       Region 4gl9 B 920-923 disorder
       Region 4gl9 B 924-1050 order
       Region 4gl9 B 1051-1052 disorder
       Region 4gl9 B 1053-1127 order
       Region 4gl9 B 1128-1129 disorder
Seq 836-1129 Hetero trimer : IID50193Complex
 Evidence X-RAY 4gl9 C Reference
       Region 4gl9 C 836-842 disorder
       Region 4gl9 C 843-919 order
       Region 4gl9 C 920-923 disorder
       Region 4gl9 C 924-1127 order
       Region 4gl9 C 1128-1129 disorder
Seq 836-1129 Hetero trimer : IID50193Complex
 Evidence X-RAY 4gl9 D Reference
       Region 4gl9 D 836-842 disorder
       Region 4gl9 D 843-919 order
       Region 4gl9 D 920-923 disorder
       Region 4gl9 D 924-1127 order
       Region 4gl9 D 1128-1129 disorder
Seqphosphorylation
    1008-1008 Phosphotyrosine; by autocatalysis
    1007-1007 Phosphotyrosine; by autocatalysis
    972-972 Phosphotyrosine; by autocatalysis
    966-966 Phosphotyrosine; by autocatalysis
    868-868 Phosphotyrosine; by autocatalysis
    813-813 Phosphotyrosine
    570-570 Phosphotyrosine
    523-523 Phosphoserine
    373-373 Phosphotyrosine
    372-372 Phosphotyrosine
    119-119 Phosphotyrosine; by autocatalysis
 
Prediction
NeProc
Disorder 1-35,302-310,511-530,824-832,1131-1132
Order 36-136,142-277,284-301,311-510,531-823,833-1130
ProS 21-27,511-525,824-832,1131-1132
AlphaFold
Disorder 1-36,50-51,126-129,138-138,275-282,301-313,333-337,514-534,810-840,859-859,920-923,1013-1013,1069-1072,1131-1132
Order 37-49,52-125,130-137,139-274,283-300,314-332,338-513,535-809,841-858,860-919,924-1012,1014-1068,1073-1130
Pfam Hmmer
PF00017 401-481 0.00052
PF07714 545-805 7.5e-80
PF07714 849-1123 6.8e-128
SEG 223-242
Function
Function in SwissProt
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation. Plays a role in cell cycle by phosphorylating CDKN1B. Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin.