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IID50094
 UniprotQ7ZUW7
ProteinProtein Mdm4
Genemdm4
OrganismDanio rerio
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
496
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 15-140 Hetero dimer : IID00015Complex
 Evidence X-RAY 2z5t O Reference
       Region 2z5t O 15-106 order
       Region 2z5t O 107-140 disorder
 Evidence X-RAY 2z5t N Reference
       Region 2z5t N 15-105 order
       Region 2z5t N 106-140 disorder
 Evidence X-RAY 2z5t M Reference
       Region 2z5t M 15-17 disorder
       Region 2z5t M 18-106 order
       Region 2z5t M 107-140 disorder
 Evidence X-RAY 2z5s O Reference
       Region 2z5s O 15-20 disorder
       Region 2z5s O 21-106 order
       Region 2z5s O 107-140 disorder
 Evidence X-RAY 2z5s N Reference
       Region 2z5s N 15-21 disorder
       Region 2z5s N 22-107 order
       Region 2z5s N 108-140 disorder
 Evidence X-RAY 2z5s M Reference
       Region 2z5s M 15-17 order
       Region 2z5s M 18-19 disorder
       Region 2z5s M 20-106 order
       Region 2z5s M 107-140 disorder
 Evidence X-RAY 3dac A Reference
       Region 3dac A 15-21 disorder
       Region 3dac A 22-106 order
       Region 3dac A 107-129 disorder
 Evidence X-RAY 3dac M Reference
       Region 3dac M 15-21 disorder
       Region 3dac M 22-106 order
       Region 3dac M 107-129 disorder
Seq 17-106 Monomer :
 Evidence X-RAY 4n5t A Reference
       Region 4n5t A 17-106 order
 
Prediction
NeProc
Disorder 1-18,112-302,342-439
Order 19-111,303-341,440-496
ProS 11-18,120-129,159-171,180-208,224-260,281-302,342-346,371-391,436-439
AlphaFold
Disorder 1-21,108-304,336-439
Order 22-107,305-335,440-496
Pfam Hmmer
PF02201 23-98 4.9e-13
SEG 146-170 ,361-370 ,397-410
Function
Function in SwissProt
Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.
Biological Process
Diagram with PDB data
mdm4/TP53Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain
See also
Diagram with PDB data
TP53/MDM4Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain