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IID50096
UniprotQ8MXE7
ProteinLin-12 And Glp-1 phenotype
Genelag-1
OrganismCaenorhabditis elegans
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
671
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 190-661 Hetero dimer : IID50027Complex
 Evidence X-RAY 3brd A Reference
       Region 3brd A 190-192 disorder
       Region 3brd A 193-261 order
       Region 3brd A 262-278 disorder
       Region 3brd A 279-302 order
       Region 3brd A 303-316 disorder
       Region 3brd A 317-371 order
       Region 3brd A 372-376 disorder
       Region 3brd A 377-430 order
       Region 3brd A 431-434 disorder
       Region 3brd A 435-659 order
       Region 3brd A 660-661 disorder
Seq 190-661 Hetero trimer : IID50027Complex,IID50087Complex
 Evidence X-RAY 2fo1 A Reference
       Region 2fo1 A 190-192 disorder
       Region 2fo1 A 193-265 order
       Region 2fo1 A 266-275 disorder
       Region 2fo1 A 276-309 order
       Region 2fo1 A 310-316 disorder
       Region 2fo1 A 317-370 order
       Region 2fo1 A 371-377 disorder
       Region 2fo1 A 378-431 order
       Region 2fo1 A 432-437 disorder
       Region 2fo1 A 438-661 order
Seq 190-661 Monomer :
 Evidence X-RAY 1ttu A Reference
       Region 1ttu A 190-192 disorder
       Region 1ttu A 193-260 order
       Region 1ttu A 261-277 disorder
       Region 1ttu A 278-302 order
       Region 1ttu A 303-316 disorder
       Region 1ttu A 317-658 order
       Region 1ttu A 659-661 disorder
 
Prediction
NeProc
Disorder 1-25,60-313,370-396,403-408,421-437,481-497,639-644,784-790
Order 26-59,314-369,397-402,409-420,438-480,498-552,561-638,645-778
ProS 1-25,60-79,87-113,386-396,403-408,421-437,481-486,639-644,784-790
Pfam Hmmer
PF01833 680-776 6.5e-11
SEG 13-25 ,97-114 ,121-145 ,170-186 ,189-210
Function
Function in SwissProt
Transcriptional regulator that plays a central role in lin-12/Notch and glp-1/Notch signaling, signaling pathways involved in cell-cell communication that regulate a broad spectrum of cell-fate determinations (PubMed:8625826). Binds directly to the 5'-[A/G]TGGGAA-3' DNA consensus sequence, which is present in the regulatory region of several genes (PubMed:8625826, PubMed:18706403, PubMed:23615264, PubMed:15297877). Acts as a transcriptional repressor when it is not associated with Notch proteins (By similarity). When in a complex with a Notch intracellular domain (NICD) product of lin-12/Notch and transcription regulator lag-3, it may act as a transcriptional activator that activates transcription of target genes (By similarity) (PubMed:18381292, PubMed:10830967). Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively (By similarity). Involved in cell-fate specification during reproductive system development, by positively autoregulating its own expression, in response to lin-12/Notch signaling (PubMed:23615264, PubMed:32839181). May repress expression of hlh-6, in a lin-12/Notch-independent manner (PubMed:18706403).