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IID50106
 UniprotQ9VPQ6
ProteinZinc finger protein ush
Geneush
OrganismDrosophila melanogaster
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1191
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 202-235 Monomer :
 Evidence NMR 1fv5 A Reference
       Region 1fv5 A 202-235 order
Seq 202-235 Hetero dimer : IID50040Complex
 Evidence NMR 1y0j B Reference
       Region 1y0j B 202-235 order
Seq 202-235 Hetero trimer : IID50040Complex
 Evidence NMR 2l6z B Reference
       Region 2l6z B 202-235 order
Seq 1113-1146 Monomer :
 Evidence NMR 1fu9 A Reference
       Region 1fu9 A 1113-1146 order
 Evidence NMR 1jn7 A Reference
       Region 1jn7 A 1113-1146 order
Seqphosphorylation
    1013-1013 Phosphoserine
    1015-1015 Phosphoserine
    1017-1017 Phosphoserine
    1156-1156 Phosphoserine
    118-118 Phosphoserine
    116-116 Phosphoserine
 
Prediction
NeProc
Disorder 1-217,224-804,816-880,946-1116,1121-1191
Order 218-223,805-815,881-945,1117-1120
ProS 1-32,152-169,207-217,224-237,274-301,338-365,446-460,482-494,540-544,580-583,594-603,722-754,768-777,785-804,816-834,843-862,876-880,946-953,971-1023,1032-1038,1043-1066,1085-1099,1113-1116,1121-1152,1182-1191
AlphaFold
Disorder 1-35,46-207,233-277,303-340,366-443,447-447,449-449,458-725,751-795,822-845,848-848,851-881,905-907,934-940,951-980,1010-1117,1144-1191
Order 36-45,208-232,278-302,341-365,444-446,448-448,450-457,726-750,796-821,846-847,849-850,882-904,908-933,941-950,981-1009,1118-1143
SEG 34-78 ,89-105 ,109-120 ,129-150 ,241-266 ,379-401 ,418-431 ,504-527 ,552-567 ,602-614 ,616-636 ,670-718 ,771-784 ,823-837 ,1107-1114 ,1160-1178
Function
Function in SwissProt
Transcription regulator that modulates expression mediated by transcription factors of the GATA family such as pnr and srp. Represses transcription of proneural achaete-scute complex (AS-C), which is usually activated by pnr. Involved in cardiogenesis, blood, and eye development. During hematopoiesis, it is required to restrict the number of crystal cells, probably via its interaction with the isoform SrpNC of srp. Negatively regulates expression of sr. Probably acts by interacting with the GATA-type zinc finger of proteins such as pnr and srp, possibly antagonizing the interaction between the GATA-type zinc finger and some cofactor.