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IID50108
 UniprotQ9Z2D7
ProteinMethyl-CpG-binding domain protein 4
GeneMbd4
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 xml
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
554
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 63-136 Homo dimer :
 Evidence X-RAY 3vyq D Reference
       Region 3vyq D 63-69 disorder
       Region 3vyq D 70-132 order
       Region 3vyq D 133-136 disorder
 Evidence X-RAY 3vyq A Reference
       Region 3vyq A 63-69 disorder
       Region 3vyq A 70-132 order
       Region 3vyq A 133-136 disorder
Seq 69-136 Monomer :
 Evidence X-RAY 3vxv A Reference
       Region 3vxv A 69-70 disorder
       Region 3vxv A 71-135 order
       Region 3vxv A 136-136 disorder
 Evidence X-RAY 3vxx A Reference
       Region 3vxx A 69-71 disorder
       Region 3vxx A 72-134 order
       Region 3vxx A 135-136 disorder
 Evidence X-RAY 3vyb A Reference
       Region 3vyb A 69-71 disorder
       Region 3vyb A 72-134 order
       Region 3vyb A 135-136 disorder
Seq 400-554 Monomer :
 Evidence X-RAY 1ngn A Reference
       Region 1ngn A 400-410 disorder
       Region 1ngn A 411-554 order
 Evidence X-RAY 4evv A Reference
       Region 4evv A 411-554 order
 Evidence X-RAY 4ew0 A Reference
       Region 4ew0 A 411-411 disorder
       Region 4ew0 A 412-554 order
 Evidence X-RAY 4ew4 A Reference
       Region 4ew4 A 411-552 order
       Region 4ew4 A 553-554 disorder
SeqProS possible 84-90 Same region of human homolog (IID00332) is disordered in the free state. Homo dimer :
       Region 3vyq A 70-132 order
       Region 3vyq D 70-132 order
SeqProS possible 84-90 Same region of human homolog (IID00332) is disordered in the free state. :
       Region 3vxv A 71-135 order
       Region 3vxx A 72-134 order
       Region 3vyb A 72-134 order
Seqphosphorylation
    402-402 Phosphoserine
    296-296 Phosphoserine
 
Prediction
NeProc
Disorder 1-70,139-377
Order 71-138,378-554
ProS 4-29,66-70,155-178,208-222,228-239,245-258,273-291,300-305,324-335,347-362,369-377
AlphaFold
Disorder 1-71,134-386,390-392,394-409
Order 72-133,387-389,393-393,410-554
Pfam Hmmer
PF01429 63-138 1.8e-27
SEG 57-67 ,178-196
Function
Function in SwissProt
Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.