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IID50109
 UniprotQ9Z2X8
ProteinKelch-like ECH-associated protein 1
GeneKeap1
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
624
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 309-624 Hetero dimer : IID50024Complex
 Evidence X-RAY 2dyh A Reference
       Region 2dyh A 309-323 disorder
       Region 2dyh A 324-619 order
       Region 2dyh A 620-624 disorder
Seq 309-624 Hetero dimer : IID50150Complex
 Evidence X-RAY 3ade A Reference
       Region 3ade A 309-324 disorder
       Region 3ade A 325-613 order
       Region 3ade A 614-624 disorder
 Evidence X-RAY 3wdz A Reference
       Region 3wdz A 321-324 disorder
       Region 3wdz A 325-609 order
Seq 309-624 Hetero dimer : IID50035Complex
 Evidence X-RAY 2z32 A Reference
       Region 2z32 A 309-323 disorder
       Region 2z32 A 324-613 order
       Region 2z32 A 614-624 disorder
Seq 309-624 Hetero dimer : IID50024Complex
 Evidence X-RAY 1x2r A Reference
       Region 1x2r A 309-323 disorder
       Region 1x2r A 324-613 order
       Region 1x2r A 614-624 disorder
Seq 309-624 Monomer :
 Evidence X-RAY 1x2j A Reference
       Region 1x2j A 309-323 disorder
       Region 1x2j A 324-613 order
       Region 1x2j A 614-624 disorder
 Evidence X-RAY 4zy3 A Reference
       Region 4zy3 A 321-324 disorder
       Region 4zy3 A 325-609 order
 Evidence X-RAY 4zy3 B Reference
       Region 4zy3 B 321-324 disorder
       Region 4zy3 B 325-609 order
 Evidence X-RAY 5cgj A Reference
       Region 5cgj A 309-323 disorder
       Region 5cgj A 324-613 order
       Region 5cgj A 614-624 disorder
 Evidence X-RAY 5fnq A Reference
       Region 5fnq A 322-323 disorder
       Region 5fnq A 324-613 order
       Region 5fnq A 614-624 disorder
 Evidence X-RAY 5fnr A Reference
       Region 5fnr A 322-324 disorder
       Region 5fnr A 325-613 order
       Region 5fnr A 614-624 disorder
 Evidence X-RAY 5fns A Reference
       Region 5fns A 322-324 disorder
       Region 5fns A 325-613 order
       Region 5fns A 614-624 disorder
 Evidence X-RAY 5fnt A Reference
       Region 5fnt A 322-324 disorder
       Region 5fnt A 325-613 order
       Region 5fnt A 614-624 disorder
 Evidence X-RAY 5fnu A Reference
       Region 5fnu A 322-325 disorder
       Region 5fnu A 326-613 order
       Region 5fnu A 614-624 disorder
 Evidence X-RAY 5fzj A Reference
       Region 5fzj A 322-324 disorder
       Region 5fzj A 325-613 order
       Region 5fzj A 614-624 disorder
 Evidence X-RAY 5fzn A Reference
       Region 5fzn A 322-323 disorder
       Region 5fzn A 324-613 order
       Region 5fzn A 614-624 disorder
Seq 321-609 Hetero dimer : IID50024Complex
 Evidence X-RAY 3wn7 A Reference
       Region 3wn7 A 321-323 disorder
       Region 3wn7 A 324-609 order
 Evidence X-RAY 3wn7 L Reference
       Region 3wn7 L 321-323 disorder
       Region 3wn7 L 324-609 order
 
Prediction
NeProc
Disorder 1-50,621-624
Order 51-311,317-620
ProS 26-31,621-624
AlphaFold
Disorder 1-51,314-318,620-624
Order 52-313,319-619
Pfam Hmmer
PF00651 67-179 4.6e-41
PF07707 184-286 6.1e-48
PF01344 315-359 8.7e-06
PF01344 361-410 1.4e-15
PF01344 412-457 4.1e-14
PF01344 459-504 2e-16
PF01344 506-551 1.1e-18
PF01344 553-598 1.1e-17
Function
Function in SwissProt
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination (PubMed:9887101, PubMed:12682069, PubMed:15282312, PubMed:15367669, PubMed:15581590). KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes (PubMed:9887101, PubMed:12193649, PubMed:14764894). In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes (PubMed:12193649, PubMed:20498371, PubMed:22014577, PubMed:29590092). In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2 (PubMed:20421418, PubMed:20173742, PubMed:24011591). The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62, increasing SQSTM1/p62 sequestering activity and degradation (PubMed:28380357). The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome (By similarity).