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IID50112
UniprotQ62625
ProteinMicrotubule-associated proteins 1A/1B light chain 3B
GeneMap1lc3b
OrganismRattus norvegicus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
142
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-120 Monomer :
 Evidence X-RAY 1ugm A Reference
       Region 1ugm A 1-4 disorder
       Region 1ugm A 5-117 order
       Region 1ugm A 118-120 disorder
Seq 1-120 Hetero dimer : IID50133Complex
 Evidence NMR 2k6q A Reference
       Region 2k6q A 1-120 order
       Region 2k6q A 1-2 high_rmsd
Seq 1-124 Hetero dimer : IID00347Complex
 Evidence X-RAY 2zzp B Reference
       Region 2zzp B 1-3 disorder
       Region 2zzp B 4-122 order
       Region 2zzp B 123-124 disorder
 Evidence X-RAY 2z0e B Reference
       Region 2z0e B 1-4 disorder
       Region 2z0e B 5-122 order
       Region 2z0e B 123-124 disorder
 Evidence X-RAY 2z0d B Reference
       Region 2z0d B 1-4 disorder
       Region 2z0d B 5-120 order
 
Prediction
NeProc
Disorder 1-6,132-142
Order 7-89,95-131
ProS 132-142
AlphaFold
Disorder 1-3,120-142
Order 4-119
Pfam Hmmer
PF02991 15-120 1.3e-69
Function
Function in SwissProt
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.