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IID50119
 UniprotP35330
ProteinIntercellular adhesion molecule 2
GeneIcam2
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
277
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 253-268 Hetero dimer : IID50114Complex
 Evidence X-RAY 1j19 B Reference
       Region 1j19 B 253-268 order
 
Prediction
NeProc
Disorder 1-19,266-277
Order 20-203,209-265
ProS 1-19,266-277
AlphaFold
Disorder 1-23,164-165,182-184,218-220,255-277
Order 24-163,166-181,185-217,221-254
Pfam Hmmer
PF03921 4-114 9.7e-80
SEG 224-243
Function
Function in SwissProt
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.