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IID50121
 UniprotP61926
ProteincAMP-dependent protein kinase inhibitor alpha
GenePKIA
OrganismOryctolagus cuniculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
76
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 6-23 Hetero dimer : IID00366Complex
 Evidence X-RAY 5uzk I Reference
       Region 5uzk I 6-23 order
Seq 6-25 Hetero dimer : IID50158Complex
 Evidence X-RAY 1cdk J Reference
       Region 1cdk J 6-25 order
 Evidence X-RAY 1cdk I Reference
       Region 1cdk I 6-25 order
Seq 6-25 Hetero tetramer : IID50158Complex
 Evidence X-RAY 1ctp I Reference
       Region 1ctp I 6-23 order
       Region 1ctp I 24-25 disorder
Seq 6-25 Hetero dimer : IID50138Complex
 Evidence X-RAY 4xw6 B Reference
       Region 4xw6 B 6-25 order
 Evidence X-RAY 4xw5 B Reference
       Region 4xw5 B 6-25 order
 Evidence X-RAY 4xw4 B Reference
       Region 4xw4 B 6-25 order
 Evidence X-RAY 1jbp S Reference
       Region 1jbp S 6-25 order
 Evidence X-RAY 1fmo I Reference
       Region 1fmo I 6-25 order
 Evidence X-RAY 2erz I Reference
       Region 2erz I 6-25 order
Seq 6-25 Hetero dimer : IID50134Complex
 Evidence X-RAY 4yxs I Reference
       Region 4yxs I 6-25 order
 Evidence X-RAY 1svg B Reference
       Region 1svg B 6-25 order
 Evidence X-RAY 1sve B Reference
       Region 1sve B 6-24 order
       Region 1sve B 25-25 disorder
 Evidence X-RAY 1stc I Reference
       Region 1stc I 6-22 order
       Region 1stc I 23-25 disorder
 Evidence X-RAY 1smh B Reference
       Region 1smh B 6-25 order
 Evidence X-RAY 1q8w B Reference
       Region 1q8w B 6-25 order
 Evidence X-RAY 2gnl I Reference
       Region 2gnl I 6-25 order
 Evidence X-RAY 2gnh I Reference
       Region 2gnh I 6-25 order
 Evidence X-RAY 2gfc I Reference
       Region 2gfc I 6-25 order
 Evidence X-RAY 2f7z I Reference
       Region 2f7z I 6-25 order
 Evidence X-RAY 3dne I Reference
       Region 3dne I 6-25 order
 Evidence X-RAY 3dnd I Reference
       Region 3dnd I 6-25 order
Seqdisorder 14-24
 Evidence CD Reference
       Region 14-24 disorder
Seqdisorder 14-34,45-76
 Evidence NMR This region takes an alpha-helix structure shown by NMR. Reference
       Region 14-34 disorder
       Region 45-76 disorder
SeqProS verified 14-23 Hetero dimer : IID00366Complex
       Region 5uzk I 6-23 order
       Region 14-34 disorder
SeqProS verified 14-23 Hetero dimer : IID50158Complex
       Region 1cdk I 6-25 order
       Region 1cdk J 6-25 order
       Region 14-34 disorder
SeqProS verified 14-23 Hetero tetramer : IID50158Complex
       Region 1ctp I 6-23 order
       Region 14-34 disorder
SeqProS verified 14-25 Hetero dimer : IID50138Complex
       Region 4xw5 B 6-25 order
       Region 4xw6 B 6-25 order
       Region 4xw4 B 6-25 order
       Region 2erz I 6-25 order
       Region 1fmo I 6-25 order
       Region 1jbp S 6-25 order
       Region 14-34 disorder
SeqProS verified 14-25 Hetero dimer : IID50134Complex
       Region 2f7z I 6-25 order
       Region 1svg B 6-25 order
       Region 3dnd I 6-25 order
       Region 2gfc I 6-25 order
       Region 1smh B 6-25 order
       Region 2gnh I 6-25 order
       Region 1q8w B 6-25 order
       Region 2gnl I 6-25 order
       Region 3dne I 6-25 order
       Region 1sve B 6-24 order
       Region 4yxs I 6-25 order
       Region 1stc I 6-22 order
       Region 14-34 disorder
       Region 14-24 disorder
Seqacetylation
    2-2 N-acetylthreonine; alternate
 
Prediction
NeProc
Disorder 1-9,20-23,29-76
Order 10-19,24-28
ProS 5-9,20-23,35-50
AlphaFold
Disorder 1-1,15-19,21-34,52-76
Order 2-14,20-20,35-51
Pfam Hmmer
PF02827 2-75 3.2e-47
Function
Function in SwissProt
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.