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IID50127
 UniprotQ60838
ProteinSegment polarity protein dishevelled homolog DVL-2
GeneDvl2
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
736
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 417-510 Monomer : IID50122Complex
 Evidence X-RAY 3ml6 A Reference
       Region 3ml6 A 417-420 disorder
       Region 3ml6 A 421-510 order
Seq 417-510 Monomer : IID50122Complex
 Evidence X-RAY 3ml6 B Reference
       Region 3ml6 B 417-420 disorder
       Region 3ml6 B 421-510 order
Seq 417-510 Monomer : IID50122Complex
 Evidence X-RAY 3ml6 F Reference
       Region 3ml6 F 417-420 disorder
       Region 3ml6 F 421-510 order
Seq 417-510 Monomer : IID50122Complex
 Evidence X-RAY 3ml6 C Reference
       Region 3ml6 C 417-420 disorder
       Region 3ml6 C 421-510 order
Seq 417-510 Monomer : IID50122Complex
 Evidence X-RAY 3ml6 E Reference
       Region 3ml6 E 417-420 disorder
       Region 3ml6 E 421-510 order
Seq 417-510 Monomer : IID50122Complex
 Evidence X-RAY 3ml6 D Reference
       Region 3ml6 D 417-420 disorder
       Region 3ml6 D 421-510 order
Seqphosphorylation
    211-211 Phosphoserine
 
Prediction
NeProc
Disorder 1-12,94-261,366-425,514-718
Order 13-93,262-365,426-513,719-736
ProS 94-107,120-126,133-181,188-197,205-235,247-251,366-382,413-425,514-522,533-540,547-554,563-579,708-718
AlphaFold
Disorder 1-11,50-51,93-263,287-291,354-374,384-416,509-736
Order 12-49,52-92,264-286,292-353,375-383,417-508
Pfam Hmmer
PF00778 11-93 4e-59
PF02377 160-232 1.1e-25
PF00595 267-352 9.6e-26
PF00610 433-505 3.6e-32
SEG 2-12 ,112-122 ,155-170 ,193-208 ,231-246 ,250-262 ,395-407 ,552-569 ,572-606 ,613-653 ,679-692
Function
Function in SwissProt
Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling.