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IID50137
 UniprotP04912
ProteinHistone H2A.2
GeneHTA2
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
132
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-132 Hetero decamer : IID50067Complex,IID50143Complex,IID50196Complex,P02309
 Evidence X-RAY 4kud G Reference
       Region 4kud G 1-15 disorder
       Region 4kud G 16-120 order
       Region 4kud G 121-132 disorder
 Evidence X-RAY 4kud C Reference
       Region 4kud C 1-16 disorder
       Region 4kud C 17-119 order
       Region 4kud C 120-132 disorder
Seq 2-132 Hetero decamer : IID50067Complex,IID50136Complex,IID50143Complex,P02309
 Evidence X-RAY 4jjn G Reference
       Region 4jjn G 2-16 disorder
       Region 4jjn G 17-122 order
       Region 4jjn G 123-132 disorder
 Evidence X-RAY 4jjn C Reference
       Region 4jjn C 2-14 disorder
       Region 4jjn C 15-119 order
       Region 4jjn C 120-132 disorder
Seqphosphorylation
    129-129 Phosphoserine
Seqacetylation
    2-2 N-acetylserine
    5-5 N6-acetyllysine
    8-8 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-24,120-132
Order 25-119
ProS 20-24
AlphaFold
Disorder 1-12,123-132
Order 13-122
Pfam Hmmer
PF00125 19-92 2.1e-30
SEG 2-24 ,55-68
Function
Function in SwissProt
Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.