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IID50140
UniprotP14907
ProteinNucleoporin NSP1
GeneNSP1
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
823
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 497-608 Hetero dimer : IID00386Complex
 Evidence X-RAY 1o6o E Reference
       Region 1o6o E 497-509 disorder
       Region 1o6o E 510-515 order
       Region 1o6o E 516-608 disorder
 Evidence X-RAY 1o6o F Reference
       Region 1o6o F 497-510 disorder
       Region 1o6o F 511-515 order
       Region 1o6o F 516-608 disorder
 Evidence X-RAY 1o6o D Reference
       Region 1o6o D 497-510 disorder
       Region 1o6o D 511-515 order
       Region 1o6o D 516-608 disorder
SeqProS predicted 511-515 The unbound state of this region is predicted to be disordered by DICHOT and MobiDB. Hetero dimer : IID00386Complex
       Region 1o6o D 511-515 order
       Region 1o6o E 510-515 order
       Region 1o6o F 511-515 order
Seqphosphorylation
    456-456 Phosphoserine
    361-361 Phosphoserine
    238-238 Phosphoserine
    631-631 Phosphoserine
 
Prediction
NeProc
Disorder 1-632,724-735,776-785,817-823
Order 633-723,736-775,786-816
ProS 626-632,817-823
AlphaFold
Disorder 1-635,727-735,779-787,823-823
Order 636-726,736-778,788-822
Pfam Hmmer
PF05064 611-733 8.9e-66
SEG 19-31 ,46-63 ,80-102 ,119-138 ,142-166 ,238-252 ,270-281 ,479-490 ,754-765 ,781-791
Function
Function in SwissProt
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NSP1 plays an important role in several nuclear transport pathways including poly(A)+ RNA, tRNA, pre-ribosome, signal recognition particle (SRP), and protein transport.