Structure
atLeast majority ProS Experiment
:order disorder conflict PDB cluster ProS Pfam Domain SEG
136
order/disorder by at least rule
disorder by at least rule
order/disorder by majority rule
Seq 1-136 Hetero octamer : IID50145 Complex ,
Q6AZJ8
Region 3mgr E 2-37 disorder
Region 3mgr E 38-136 order
Region 3mgr A 2-37 disorder
Region 3mgr A 38-136 order
Region 3lz1 E 2-39 disorder
Region 3lz1 E 40-136 order
Region 3lz1 A 2-38 disorder
Region 3lz1 A 39-135 order
Region 3lz1 A 136-136 disorder
Region 3lz0 E 2-39 disorder
Region 3lz0 E 40-136 order
Region 3lz0 A 2-38 disorder
Region 3lz0 A 39-135 order
Region 3lz0 A 136-136 disorder
Region 3lel E 1-38 disorder
Region 3lel E 39-136 order
Region 3lel A 1-38 disorder
Region 3lel A 39-136 order
Region 3kxb E 2-45 disorder
Region 3kxb E 46-135 order
Region 3kxb E 136-136 disorder
Region 3kxb A 2-42 disorder
Region 3kxb A 43-134 order
Region 3kxb A 135-136 disorder
Region 4kgc E 1-38 disorder
Region 4kgc E 39-135 order
Region 4kgc E 136-136 disorder
Region 4kgc A 1-38 disorder
Region 4kgc A 39-135 order
Region 4kgc A 136-136 disorder
Seq 1-136 Hetero octamer : IID00019 Complex ,
P62806
Region 1f66 E 1-33 disorder
Region 1f66 E 34-136 order
Region 1f66 A 1-36 disorder
Region 1f66 A 37-136 order
Seq 1-136 Hetero octadecamer : IID50139 Complex ,
IID50145 Complex
Region 4zux O 1-39 disorder
Region 4zux O 40-136 order
Region 4zux K 1-38 disorder
Region 4zux K 39-135 order
Region 4zux K 136-136 disorder
Region 2f8n E 1-38 disorder
Region 2f8n E 39-136 order
Region 2f8n A 1-38 disorder
Region 2f8n A 39-136 order
Seq 1-136 Hetero decamer : IID50067 Complex ,
IID50139 Complex ,
IID50145 Complex
Region 4ld9 E 1-44 disorder
Region 4ld9 E 45-134 order
Region 4ld9 E 135-136 disorder
Region 4ld9 A 1-37 disorder
Region 4ld9 A 38-134 order
Region 4ld9 A 135-136 disorder
Seq 1-136 Hetero octadecamer : IID50139 Complex ,
IID50145 Complex
Region 4zux E 1-39 disorder
Region 4zux E 40-136 order
Region 4zux A 1-38 disorder
Region 4zux A 39-135 order
Region 4zux A 136-136 disorder
Seq 1-136 Hetero nonamer : IID50139 Complex ,
IID50145 Complex
Region 5e5a E 1-38 disorder
Region 5e5a E 39-136 order
Region 5e5a A 1-37 disorder
Region 5e5a A 38-136 order
Seq 1-136 Hetero octamer : IID50145 Complex ,
Q6AZJ8
Region 3lel O 1-38 disorder
Region 3lel O 39-136 order
Region 3lel K 1-37 disorder
Region 3lel K 38-136 order
Seq 2-16 Hetero dimer : IID00362 Complex
Region 3gv6 B 2-5 disorder
Region 3gv6 B 12-16 disorder
Seq 2-136 Hetero dodecamer : IID00450 Complex ,
IID50139 Complex ,
IID50145 Complex
Region 4r8p E 2-38 disorder
Region 4r8p E 39-135 order
Region 4r8p E 136-136 disorder
Region 4r8p A 2-37 disorder
Region 4r8p A 38-135 order
Region 4r8p A 136-136 disorder
Seq 2-136 Hetero decamer : IID50145 Complex ,
Q6AZJ8
Region 3mvd E 2-40 disorder
Region 3mvd E 41-135 order
Region 3mvd E 136-136 disorder
Region 3mvd A 2-37 disorder
Region 3mvd A 38-135 order
Region 3mvd A 136-136 disorder
Seq 2-136 Hetero trimer : IID00182 Complex ,
IID50145 Complex
Region 2io5 B 2-60 disorder
Region 2io5 B 61-136 order
Seq 2-136 Hetero octamer : IID50145 Complex ,
Q6AZJ8
Region 3mgq E 2-37 disorder
Region 3mgq E 38-136 order
Region 3mgq A 2-37 disorder
Region 3mgq A 38-136 order
Region 3mgp E 2-37 disorder
Region 3mgp E 38-136 order
Region 3mgp A 2-37 disorder
Region 3mgp A 38-136 order
Seq 2-136 Hetero octamer : IID50139 Complex ,
IID50145 Complex
Region 2fj7 E 2-38 disorder
Region 2fj7 E 39-136 order
Region 2fj7 A 2-38 disorder
Region 2fj7 A 39-136 order
Region 3b6f E 2-31 disorder
Region 3b6f E 32-136 order
Region 3b6f A 2-33 disorder
Region 3b6f A 34-136 order
Seq 2-136 Hetero octamer : IID50139 Complex ,
IID50145 Complex
Region 4z66 E 39-136 order
Region 4z66 A 39-136 order
Region 4xzq E 39-136 order
Region 4xzq A 39-136 order
Region 5xf6 E 2-38 disorder
Region 5xf6 E 39-135 order
Region 5xf6 E 136-136 disorder
Region 5xf6 A 2-38 disorder
Region 5xf6 A 39-135 order
Region 5xf6 A 136-136 disorder
Region 4wu9 E 2-38 disorder
Region 4wu9 E 39-134 order
Region 4wu9 E 135-136 disorder
Region 4wu9 A 2-38 disorder
Region 4wu9 A 39-134 order
Region 4wu9 A 135-136 disorder
Region 3utb E 2-39 disorder
Region 3utb E 40-136 order
Region 3utb A 2-38 disorder
Region 3utb A 39-136 order
Region 3uta E 2-38 disorder
Region 3uta E 39-135 order
Region 3uta E 136-136 disorder
Region 3uta A 2-38 disorder
Region 3uta A 39-135 order
Region 3uta A 136-136 disorder
Region 3ut9 E 2-38 disorder
Region 3ut9 E 39-135 order
Region 3ut9 E 136-136 disorder
Region 3ut9 A 2-38 disorder
Region 3ut9 A 39-136 order
Region 1s32 E 2-37 disorder
Region 1s32 E 38-136 order
Region 1s32 A 2-38 disorder
Region 1s32 A 39-136 order
Region 3rel E 2-39 disorder
Region 3rel E 40-136 order
Region 3rel A 2-38 disorder
Region 3rel A 39-136 order
Region 3rek E 2-39 disorder
Region 3rek E 40-136 order
Region 3rek A 2-38 disorder
Region 3rek A 39-136 order
Region 3rej E 2-39 disorder
Region 3rej E 40-136 order
Region 3rej A 2-38 disorder
Region 3rej A 39-136 order
Region 1p3p E 2-36 disorder
Region 1p3p E 37-136 order
Region 1p3p A 2-36 disorder
Region 1p3p A 37-136 order
Region 1p3m E 2-37 disorder
Region 1p3m E 38-136 order
Region 1p3m A 2-37 disorder
Region 1p3m A 38-136 order
Region 1p3l E 2-37 disorder
Region 1p3l E 38-136 order
Region 1p3l A 2-38 disorder
Region 1p3l A 39-136 order
Region 1p34 E 2-38 disorder
Region 1p34 E 39-134 order
Region 1p34 E 135-136 disorder
Region 1p34 A 2-38 disorder
Region 1p34 A 39-136 order
Region 5ong E 2-39 disorder
Region 5ong E 40-136 order
Region 5ong A 2-39 disorder
Region 5ong A 40-135 order
Region 5ong A 136-136 disorder
Region 3o62 E 2-38 disorder
Region 3o62 E 39-136 order
Region 3o62 A 2-38 disorder
Region 3o62 A 39-136 order
Region 2nzd E 2-38 disorder
Region 2nzd E 39-135 order
Region 2nzd E 136-136 disorder
Region 2nzd A 2-38 disorder
Region 2nzd A 39-135 order
Region 2nzd A 136-136 disorder
Region 3mnn E 2-38 disorder
Region 3mnn E 39-135 order
Region 3mnn E 136-136 disorder
Region 3mnn A 2-38 disorder
Region 3mnn A 39-135 order
Region 3mnn A 136-136 disorder
Region 1kx5 E 2-136 order
Region 1kx5 A 2-136 order
Region 1kx4 E 2-39 disorder
Region 1kx4 E 40-136 order
Region 1kx4 A 2-38 disorder
Region 1kx4 A 39-136 order
Region 1kx3 E 2-38 disorder
Region 1kx3 E 39-136 order
Region 1kx3 A 2-38 disorder
Region 1kx3 A 39-136 order
Region 3kwq E 39-136 order
Region 3kwq A 39-136 order
Region 3kuy E 2-38 disorder
Region 3kuy E 39-134 order
Region 3kuy E 135-136 disorder
Region 3kuy A 2-38 disorder
Region 3kuy A 39-134 order
Region 3kuy A 135-136 disorder
Region 5cp6 E 2-38 disorder
Region 5cp6 E 39-134 order
Region 5cp6 E 135-136 disorder
Region 5cp6 A 2-38 disorder
Region 5cp6 A 39-134 order
Region 5cp6 A 135-136 disorder
Region 3b6g E 2-31 disorder
Region 3b6g E 32-136 order
Region 3b6g A 2-33 disorder
Region 3b6g A 34-136 order
Seq 2-136 Hetero octamer : IID50139 Complex ,
IID50145 Complex
Region 5f99 E 2-37 disorder
Region 5f99 E 38-136 order
Region 5f99 A 2-36 disorder
Region 5f99 A 37-136 order
Seq 2-136 Hetero 32mer : IID50139 Complex ,
IID50145 Complex
Region 5oy7 c 2-39 disorder
Region 5oy7 c 40-136 order
Region 5oy7 Y 2-38 disorder
Region 5oy7 Y 39-135 order
Region 5oy7 Y 136-136 disorder
Region 5oy7 U 2-39 disorder
Region 5oy7 U 40-136 order
Region 5oy7 Q 2-38 disorder
Region 5oy7 Q 39-135 order
Region 5oy7 Q 136-136 disorder
Region 5oy7 M 2-39 disorder
Region 5oy7 M 40-136 order
Region 5oy7 I 2-38 disorder
Region 5oy7 I 39-135 order
Region 5oy7 I 136-136 disorder
Region 5oy7 E 2-39 disorder
Region 5oy7 E 40-136 order
Region 5oy7 A 2-38 disorder
Region 5oy7 A 39-135 order
Region 5oy7 A 136-136 disorder
Seq 2-136 Hetero 32mer : IID50139 Complex ,
IID50145 Complex
Region 1zbb E 2-39 disorder
Region 1zbb E 40-136 order
Region 1zbb A 2-39 disorder
Region 1zbb A 40-136 order
Seq 2-136 Hetero octamer : IID50139 Complex ,
IID50145 Complex
Region 3c1c E 2-38 disorder
Region 3c1c E 39-135 order
Region 3c1c E 136-136 disorder
Region 3c1c A 2-38 disorder
Region 3c1c A 39-136 order
Seq 2-136 Hetero tetramer : IID50145 Complex
Region 5nl0 K 2-38 disorder
Region 5nl0 K 39-136 order
Region 4j8x E 2-38 disorder
Region 4j8x E 39-135 order
Region 4j8x E 136-136 disorder
Region 4j8x A 2-38 disorder
Region 4j8x A 39-135 order
Region 4j8x A 136-136 disorder
Region 4j8v E 2-38 disorder
Region 4j8v E 39-135 order
Region 4j8v E 136-136 disorder
Region 4j8v A 2-38 disorder
Region 4j8v A 39-135 order
Region 4j8v A 136-136 disorder
Seq 2-136 Hetero dodecamer : IID00101 Complex ,
IID50139 Complex ,
IID50145 Complex
Region 5hq2 A 2-37 disorder
Region 5hq2 A 38-136 order
Seq 2-136 Hetero nonamer : IID50139 Complex ,
IID50145 Complex
Region 5nl0 E 2-38 disorder
Region 5nl0 E 39-135 order
Region 5nl0 E 136-136 disorder
Region 5nl0 A 2-38 disorder
Region 5nl0 A 39-136 order
Seq 2-136 Hetero octamer : IID50139 Complex ,
IID50145 Complex
Region 4wu8 E 2-38 disorder
Region 4wu8 E 39-134 order
Region 4wu8 E 135-136 disorder
Region 4wu8 A 2-38 disorder
Region 4wu8 A 39-134 order
Region 4wu8 A 135-136 disorder
Region 3rei E 2-38 disorder
Region 3rei E 39-135 order
Region 3rei E 136-136 disorder
Region 3rei A 2-38 disorder
Region 3rei A 39-135 order
Region 3rei A 136-136 disorder
Region 3reh E 2-38 disorder
Region 3reh E 39-135 order
Region 3reh E 136-136 disorder
Region 3reh A 2-38 disorder
Region 3reh A 39-135 order
Region 3reh A 136-136 disorder
Region 1p3f E 2-37 disorder
Region 1p3f E 38-136 order
Region 1p3f A 2-37 disorder
Region 1p3f A 38-136 order
Region 1p3b E 2-37 disorder
Region 1p3b E 38-136 order
Region 1p3b A 2-37 disorder
Region 1p3b A 38-136 order
Region 5onw E 2-39 disorder
Region 5onw E 40-134 order
Region 5onw E 135-136 disorder
Region 5onw A 2-39 disorder
Region 5onw A 40-135 order
Region 5onw A 136-136 disorder
Region 3lja E 2-37 disorder
Region 3lja E 38-136 order
Region 3lja A 2-37 disorder
Region 3lja A 38-136 order
Region 5dnn E 2-38 disorder
Region 5dnn E 39-135 order
Region 5dnn E 136-136 disorder
Region 5dnn A 2-38 disorder
Region 5dnn A 39-135 order
Region 5dnn A 136-136 disorder
Region 5dnm E 2-38 disorder
Region 5dnm E 39-135 order
Region 5dnm E 136-136 disorder
Region 5dnm A 2-38 disorder
Region 5dnm A 39-135 order
Region 5dnm A 136-136 disorder
Seq 2-136 Hetero decamer : IID50067 Complex ,
IID50139 Complex ,
IID50145 Complex
Region 3tu4 E 2-40 disorder
Region 3tu4 E 41-135 order
Region 3tu4 E 136-136 disorder
Region 3tu4 A 2-37 disorder
Region 3tu4 A 38-135 order
Region 3tu4 A 136-136 disorder
Seq 2-136 Hetero hexadecamer : IID50139 Complex ,
IID50145 Complex
Region 5oxv O 2-39 disorder
Region 5oxv O 40-136 order
Region 5oxv K 2-38 disorder
Region 5oxv K 39-135 order
Region 5oxv K 136-136 disorder
Region 5oxv E 2-39 disorder
Region 5oxv E 40-136 order
Region 5oxv A 2-38 disorder
Region 5oxv A 39-135 order
Region 5oxv A 136-136 disorder
Seq 2-136 Hetero octamer : IID50139 Complex ,
IID50145 Complex
Region 4ys3 E 39-136 order
Region 4ys3 A 39-136 order
Region 4xuj E 2-38 disorder
Region 4xuj E 39-135 order
Region 4xuj E 136-136 disorder
Region 4xuj A 2-38 disorder
Region 4xuj A 39-135 order
Region 4xuj A 136-136 disorder
Region 5omx E 2-37 disorder
Region 5omx E 38-136 order
Region 5omx A 2-38 disorder
Region 5omx A 39-135 order
Region 5omx A 136-136 disorder
Seq 2-136 Hetero octamer : IID50139 Complex ,
IID50145 Complex
Region 3c1b E 2-37 disorder
Region 3c1b E 38-136 order
Region 3c1b A 2-38 disorder
Region 3c1b A 39-136 order
Seq 2-136 Hetero octamer : IID50145 Complex ,
Q6AZJ8
Region 3mgs E 2-37 disorder
Region 3mgs E 38-136 order
Region 3mgs A 2-37 disorder
Region 3mgs A 38-136 order
Seq 2-136 Hetero tetramer : IID50139 Complex ,
IID50145 Complex
Region 4j8w E 2-38 disorder
Region 4j8w E 39-135 order
Region 4j8w E 136-136 disorder
Region 4j8w A 2-38 disorder
Region 4j8w A 39-135 order
Region 4j8w A 136-136 disorder
Region 4j8u E 2-38 disorder
Region 4j8u E 39-135 order
Region 4j8u E 136-136 disorder
Region 4j8u A 2-38 disorder
Region 4j8u A 39-135 order
Region 4j8u A 136-136 disorder
Seq 2-136 Hetero octamer : IID50139 Complex ,
IID50145 Complex
Region 1p3o E 2-39 disorder
Region 1p3o E 40-136 order
Region 1p3o A 2-38 disorder
Region 1p3o A 39-136 order
Region 1p3k E 2-37 disorder
Region 1p3k E 38-136 order
Region 1p3k A 2-39 disorder
Region 1p3k A 40-136 order
Region 1p3i E 2-32 disorder
Region 1p3i E 33-136 order
Region 1p3i A 2-38 disorder
Region 1p3i A 39-136 order
Region 1p3g E 2-38 disorder
Region 1p3g E 39-136 order
Region 1p3g A 2-38 disorder
Region 1p3g A 39-136 order
Region 1p3a E 2-38 disorder
Region 1p3a E 39-136 order
Region 1p3a A 2-38 disorder
Region 1p3a A 39-136 order
Seq 2-136 Hetero nonamer : IID50139 Complex ,
IID50145 Complex
Region 1zla E 2-38 disorder
Region 1zla E 39-136 order
Region 1zla A 2-38 disorder
Region 1zla A 39-136 order
Seq 26-136 Hetero pentamer : IID50145 Complex ,
Q68D10
Region 5bsa B 27-60 disorder
Region 5bsa B 61-136 order
Region 5bsa A 27-60 disorder
Region 5bsa A 61-135 order
Region 5bsa A 136-136 disorder
Region 5bs7 B 26-60 disorder
Region 5bs7 B 61-136 order
Region 5bs7 A 26-60 disorder
Region 5bs7 A 61-135 order
Region 5bs7 A 136-136 disorder
Seq 40-136 Hetero nonamer : IID50139 Complex ,
IID50145 Complex ,
P14349
Region 5mlu E 40-136 order
Region 5mlu A 40-136 order
Seq 62-136 Hetero trimer : IID50145 Complex ,
IID50170 Complex
Region 2hue B 62-135 order
Region 2hue B 136-136 disorder
Region 4eo5 B 62-136 order
Seq ProS verified 6-11 Hetero dimer : IID00362 Complex
Region 2nzd A 2-38 disorder
4-4 Phosphothreonine; by HASPIN
7-7 Phosphothreonine; by PKC
11-11 Phosphoserine; alternate; by AURKB
12-12 Phosphothreonine; by PKC
29-29 Phosphoserine; alternate; by AURKB
5-5 N6-acetyllysine; alternate
10-10 N6-acetyllysine; alternate
19-19 N6-acetyllysine; alternate
24-24 N6-acetyllysine; alternate
28-28 N6-acetyllysine; alternate
37-37 N6-acetyllysine; alternate
57-57 N6-acetyllysine; alternate
80-80 N6-acetyllysine; alternate
116-116 N6-acetyllysine; alternate
123-123 N6-acetyllysine; alternate
Prediction
Disorder 1-3,6-35,136-136
Function
Function in SwissProt
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.