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IID50151
UniprotQ6P5F9
ProteinExportin-1
GeneXpo1
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1071
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-1071 Hetero dimer : IID00162Complex
 Evidence X-RAY 3nc1 A Reference
       Region 3nc1 A 1-9 disorder
       Region 3nc1 A 10-389 order
       Region 3nc1 A 390-400 disorder
       Region 3nc1 A 401-964 order
       Region 3nc1 A 965-968 disorder
       Region 3nc1 A 969-1050 order
       Region 3nc1 A 1051-1071 disorder
Seq 1-1071 Hetero tetramer : IID00115Complex,IID00162Complex
 Evidence X-RAY 3nbz D Reference
       Region 3nbz D 1-10 disorder
       Region 3nbz D 11-66 order
       Region 3nbz D 67-70 disorder
       Region 3nbz D 71-1052 order
       Region 3nbz D 1053-1071 disorder
 Evidence X-RAY 3nbz A Reference
       Region 3nbz A 1-10 disorder
       Region 3nbz A 11-66 order
       Region 3nbz A 67-70 disorder
       Region 3nbz A 71-1052 order
       Region 3nbz A 1053-1071 disorder
Seq 1-1071 Hetero pentamer : IID00115Complex,IID00162Complex
 Evidence X-RAY 3nc0 D Reference
       Region 3nc0 D 1-7 disorder
       Region 3nc0 D 8-67 order
       Region 3nc0 D 68-71 disorder
       Region 3nc0 D 72-1052 order
       Region 3nc0 D 1053-1071 disorder
 Evidence X-RAY 3nc0 A Reference
       Region 3nc0 A 1-10 disorder
       Region 3nc0 A 11-66 order
       Region 3nc0 A 67-70 disorder
       Region 3nc0 A 71-1052 order
       Region 3nc0 A 1053-1071 disorder
Seq 1-1071 Hetero trimer : IID00115Complex,IID00162Complex
 Evidence X-RAY 3nby D Reference
       Region 3nby D 1-11 disorder
       Region 3nby D 12-66 order
       Region 3nby D 67-69 disorder
       Region 3nby D 70-1055 order
       Region 3nby D 1056-1071 disorder
 Evidence X-RAY 3nby A Reference
       Region 3nby A 1-11 disorder
       Region 3nby A 12-66 order
       Region 3nby A 67-69 disorder
       Region 3nby A 70-1055 order
       Region 3nby A 1056-1071 disorder
 Evidence X-RAY 3gjx D Reference
       Region 3gjx D 1-11 disorder
       Region 3gjx D 12-66 order
       Region 3gjx D 67-69 disorder
       Region 3gjx D 70-1055 order
       Region 3gjx D 1056-1071 disorder
 Evidence X-RAY 3gjx A Reference
       Region 3gjx A 1-11 disorder
       Region 3gjx A 12-66 order
       Region 3gjx A 67-69 disorder
       Region 3gjx A 70-1055 order
       Region 3gjx A 1056-1071 disorder
Seq 1-1071 Hetero hexamer : IID00115Complex,IID00162Complex
 Evidence X-RAY 3nc0 D Reference
       Region 3nc0 D 1-7 disorder
       Region 3nc0 D 8-67 order
       Region 3nc0 D 68-71 disorder
       Region 3nc0 D 72-1052 order
       Region 3nc0 D 1053-1071 disorder
 Evidence X-RAY 3nc0 A Reference
       Region 3nc0 A 1-10 disorder
       Region 3nc0 A 11-66 order
       Region 3nc0 A 67-70 disorder
       Region 3nc0 A 71-1052 order
       Region 3nc0 A 1053-1071 disorder
Seqphosphorylation
    391-391 Phosphoserine
    448-448 Phosphothreonine
    450-450 Phosphoserine
    454-454 Phosphotyrosine
    1031-1031 Phosphoserine
Seqacetylation
    446-446 N6-acetyllysine
    693-693 N6-acetyllysine
 
Prediction
NeProc
Disorder 1-13,390-394,1064-1071
Order 14-385,395-1063
ProS 1064-1071
AlphaFold
Disorder 1-10,12-12,385-401,1025-1033,1054-1071
Order 11-11,13-384,402-1024,1034-1053
Pfam Hmmer
PF03810 46-112 3.6e-14
PF08389 123-268 9.1e-61
Function
Function in SwissProt
Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase Ran in its active GTP-bound form. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap (By similarity).