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IID50152
 UniprotQ8BX09
ProteinRetinoblastoma-binding protein 5
GeneRbbp5
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
538
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 369-381 Hetero trimer : IID50144Complex
 Evidence X-RAY 2xl3 E Reference
       Region 2xl3 E 369-372 disorder
       Region 2xl3 E 373-381 order
 Evidence X-RAY 2xl3 C Reference
       Region 2xl3 C 369-371 disorder
       Region 2xl3 C 372-381 order
Seq 369-381 Hetero dimer : IID50144Complex
 Evidence X-RAY 2xl2 D Reference
       Region 2xl2 D 369-371 disorder
       Region 2xl2 D 372-381 order
 Evidence X-RAY 2xl2 C Reference
       Region 2xl2 C 369-371 disorder
       Region 2xl2 C 372-381 order
SeqProS possible 372-381 This region is described to be disordered in the free state. (PubMed=20716525) Hetero dimer : IID50144Complex
       Region 2xl2 C 372-381 order
       Region 2xl2 D 372-381 order
SeqProS possible 372-381 This region is described to be disordered in the free state. (PubMed=20716525) Hetero trimer : IID50144Complex
       Region 2xl3 C 372-381 order
       Region 2xl3 E 373-381 order
Seqphosphorylation
    350-350 Phosphoserine
    388-388 Phosphoserine
    389-389 Phosphoserine
    497-497 Phosphoserine; by CDK1
    525-525 Phosphoserine
    252-252 Phosphothreonine; by CDK1
 
Prediction
NeProc
Disorder 365-397,402-538
Order 1-364,398-401
ProS 365-397,402-415,453-471,496-538
AlphaFold
Disorder 1-10,356-370,405-451,464-464,472-538
Order 11-355,371-404,452-463,465-471
Pfam Hmmer
PF00400 56-94 3.8e-07
SEG 309-320 ,344-358
Function
Function in SwissProt
In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (PubMed:21335234). Does not affect ES cell self-renewal (PubMed:21335234). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (By similarity). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3 (By similarity). Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (By similarity). In association with ASH2L and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (By similarity).