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IID50155
 UniprotQ9PTN2
ProteinVitamin D3 receptor A
Genevdra
OrganismDanio rerio
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
453
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 156-453 Hetero dimer : IID00083Complex
 Evidence X-RAY 2hbh A Reference
       Region 2hbh A 156-190 order
       Region 2hbh A 191-250 disorder
       Region 2hbh A 251-452 order
       Region 2hbh A 453-453 disorder
 Evidence X-RAY 2hc4 A Reference
       Region 2hc4 A 156-190 order
       Region 2hc4 A 191-250 disorder
       Region 2hc4 A 251-452 order
       Region 2hc4 A 453-453 disorder
 Evidence X-RAY 2hcd A Reference
       Region 2hcd A 156-190 order
       Region 2hcd A 191-250 disorder
       Region 2hcd A 251-452 order
       Region 2hcd A 453-453 disorder
 Evidence X-RAY 3dr1 A Reference
       Region 3dr1 A 156-190 order
       Region 3dr1 A 191-250 disorder
       Region 3dr1 A 251-452 order
       Region 3dr1 A 453-453 disorder
 Evidence X-RAY 4g1d A Reference
       Region 4g1d A 156-190 order
       Region 4g1d A 191-250 disorder
       Region 4g1d A 251-452 order
       Region 4g1d A 453-453 disorder
 Evidence X-RAY 4g1y A Reference
       Region 4g1y A 156-190 order
       Region 4g1y A 191-250 disorder
       Region 4g1y A 251-452 order
       Region 4g1y A 453-453 disorder
 Evidence X-RAY 4g1z A Reference
       Region 4g1z A 156-190 order
       Region 4g1z A 191-250 disorder
       Region 4g1z A 251-452 order
       Region 4g1z A 453-453 disorder
 Evidence X-RAY 4g20 A Reference
       Region 4g20 A 156-190 order
       Region 4g20 A 191-250 disorder
       Region 4g20 A 251-452 order
       Region 4g20 A 453-453 disorder
 Evidence X-RAY 4g21 A Reference
       Region 4g21 A 156-190 order
       Region 4g21 A 191-250 disorder
       Region 4g21 A 251-452 order
       Region 4g21 A 453-453 disorder
 Evidence X-RAY 4g2h A Reference
       Region 4g2h A 156-190 order
       Region 4g2h A 191-250 disorder
       Region 4g2h A 251-452 order
       Region 4g2h A 453-453 disorder
 Evidence X-RAY 5e7v A Reference
       Region 5e7v A 156-190 order
       Region 5e7v A 191-250 disorder
       Region 5e7v A 251-452 order
       Region 5e7v A 453-453 disorder
 Evidence X-RAY 5nky A Reference
       Region 5nky A 156-190 order
       Region 5nky A 191-250 disorder
       Region 5nky A 251-452 order
       Region 5nky A 453-453 disorder
 Evidence X-RAY 5ow7 A Reference
       Region 5ow7 A 156-190 order
       Region 5ow7 A 191-250 disorder
       Region 5ow7 A 251-453 order
 Evidence X-RAY 5ow9 A Reference
       Region 5ow9 A 156-190 order
       Region 5ow9 A 191-250 disorder
       Region 5ow9 A 251-452 order
       Region 5ow9 A 453-453 disorder
 Evidence X-RAY 5owd A Reference
       Region 5owd A 156-190 order
       Region 5owd A 191-251 disorder
       Region 5owd A 252-453 order
Seq 156-453 Hetero dimer : IID00082Complex
 Evidence X-RAY 3o1d A Reference
       Region 3o1d A 156-190 order
       Region 3o1d A 191-250 disorder
       Region 3o1d A 251-453 order
 Evidence X-RAY 3o1e A Reference
       Region 3o1e A 156-190 order
       Region 3o1e A 191-251 disorder
       Region 3o1e A 252-453 order
 Evidence X-RAY 4fhh A Reference
       Region 4fhh A 156-190 order
       Region 4fhh A 191-250 disorder
       Region 4fhh A 251-452 order
       Region 4fhh A 453-453 disorder
 Evidence X-RAY 4fhi A Reference
       Region 4fhi A 156-190 order
       Region 4fhi A 191-250 disorder
       Region 4fhi A 251-452 order
       Region 4fhi A 453-453 disorder
 Evidence X-RAY 4q0a C Reference
       Region 4q0a C 156-190 order
       Region 4q0a C 191-250 disorder
       Region 4q0a C 251-453 order
 Evidence X-RAY 5lga A Reference
       Region 5lga A 156-190 order
       Region 5lga A 191-251 disorder
       Region 5lga A 252-452 order
       Region 5lga A 453-453 disorder
Seq 156-453 Hetero tetramer : IID00083Complex
 Evidence X-RAY 4ruj A Reference
       Region 4ruj A 156-190 order
       Region 4ruj A 191-250 disorder
       Region 4ruj A 251-453 order
 Evidence X-RAY 4rup A Reference
       Region 4rup A 156-190 order
       Region 4rup A 191-250 disorder
       Region 4rup A 251-452 order
       Region 4rup A 453-453 disorder
 Evidence X-RAY 5nma A Reference
       Region 5nma A 156-190 order
       Region 5nma A 191-250 disorder
       Region 5nma A 251-452 order
       Region 5nma A 453-453 disorder
Seq 156-453 Hetero tetramer : IID00082Complex
 Evidence X-RAY 4ia1 A Reference
       Region 4ia1 A 156-190 order
       Region 4ia1 A 191-250 disorder
       Region 4ia1 A 251-452 order
       Region 4ia1 A 453-453 disorder
 Evidence X-RAY 4ia2 A Reference
       Region 4ia2 A 156-190 order
       Region 4ia2 A 191-250 disorder
       Region 4ia2 A 251-452 order
       Region 4ia2 A 453-453 disorder
 Evidence X-RAY 4ia3 A Reference
       Region 4ia3 A 156-190 order
       Region 4ia3 A 191-250 disorder
       Region 4ia3 A 251-452 order
       Region 4ia3 A 453-453 disorder
 Evidence X-RAY 4ia7 A Reference
       Region 4ia7 A 156-190 order
       Region 4ia7 A 191-250 disorder
       Region 4ia7 A 251-452 order
       Region 4ia7 A 453-453 disorder
 Evidence X-RAY 4ruo X Reference
       Region 4ruo X 156-190 order
       Region 4ruo X 191-250 disorder
       Region 4ruo X 251-452 order
       Region 4ruo X 453-453 disorder
 
Prediction
NeProc
Disorder 1-52,134-249,451-453
Order 53-133,250-450
ProS 24-27,134-144,169-190,212-220,230-235
AlphaFold
Disorder 1-50,193-250,450-453
Order 51-192,251-449
Pfam Hmmer
PF00105 54-129 3.5e-48
PF00104 263-447 5.8e-46
SEG 141-153 ,196-214 ,348-361
Function
Function in SwissProt
Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
Biological Process
See also
Diagram with PDB data
NCOA1/RARACrystal structure of RARalpha ligand binding domain in complex with an agonist ligand (Am580) and a coactivator fragment