IDEAL List

IDEAL

IID50161
UniprotQ9Y0H4
ProteinE3 ubiquitin-protein ligase Su(dx)
GeneSu(dx)
OrganismDrosophila melanogaster
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
Network xml rdf

Structure

Experiment

:order disorder conflict PDB cluster ProS Pfam Domain SEG

949

order/disorder by at least rule

disorder by at least rule

order by at least rule

order/disorder by majority rule

Seq 474-554 Monomer :

Evidence NMR 1tk7 A Reference

Region 1tk7 A 474-554 order

Seq 515-557 Hetero dimer : IID50157Complex

Evidence NMR 2jmf A Reference

Region 2jmf A 515-557 order

Region 2jmf A 515-519 high_rmsd

Region 2jmf A 556-557 high_rmsd

Prediction

NeProc

Disorder 1-47,156-160,172-489,511-517

Order 48-155,161-171,490-510,518-949

ProS 10-21,156-160,172-179,267-285,369-384,389-429,473-489

AlphaFold

Disorder 1-46,63-63,181-218,226-363,388-388,442-477,510-523,525-526,528-528,530-530,532-533,535-536,540-540,542-543,550-550,554-576,631-634,636-636,661-667,757-760,885-885,942-949

Order 47-62,64-180,219-225,364-387,389-441,478-509,524-524,527-527,529-529,531-531,534-534,537-539,541-541,544-549,551-553,577-630,635-635,637-660,668-756,761-884,886-941

Pfam Hmmer

PF00168 51-129 7.7e-14

PF00397 365-394 5.3e-13

PF00397 397-426 5.5e-15

PF00397 479-508 8.3e-14

PF00397 523-552 3.7e-12

PF00632 644-949 3.2e-184

SEG 24-44 ,228-236 ,261-271 ,281-304 ,315-337 ,456-470 ,771-782

Function

Function in SwissProt

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Down-regulates Notch/N signaling pathway, probably by promoting Notch ubiquitination, endocytosis and degradation. Involved in wing growth and leg joint formation.