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IID50163
 UniprotO88508
ProteinDNA (cytosine-5)-methyltransferase 3A
GeneDnmt3a
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
908
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 39-50 Hetero dimer : IID00500Complex
 Evidence X-RAY 3sw9 P Reference
       Region 3sw9 P 39-40 disorder
       Region 3sw9 P 41-45 order
       Region 3sw9 P 46-50 disorder
 Evidence X-RAY 3sw9 Q Reference
       Region 3sw9 Q 39-40 disorder
       Region 3sw9 Q 41-46 order
       Region 3sw9 Q 47-50 disorder
 Evidence X-RAY 3swc P Reference
       Region 3swc P 39-40 disorder
       Region 3swc P 41-49 order
       Region 3swc P 50-50 disorder
 Evidence X-RAY 3swc Q Reference
       Region 3swc Q 39-41 disorder
       Region 3swc Q 42-49 order
       Region 3swc Q 50-50 disorder
SeqProS predicted 41-49 The unbound state of this region is predicted to be disordered by DICHOT and MobiDB. Hetero dimer : IID00500Complex
       Region 3sw9 P 41-45 order
       Region 3sw9 Q 41-46 order
       Region 3swc P 41-49 order
       Region 3swc Q 42-49 order
Seqphosphorylation
    251-251 Phosphoserine
    257-257 Phosphothreonine
    239-239 Phosphoserine
    386-386 Phosphoserine
    102-102 Phosphoserine
    120-120 Phosphothreonine
    389-389 Phosphoserine
 
Prediction
NeProc
Disorder 1-277,388-391,427-431,438-465
Order 278-387,392-426,432-437,466-908
ProS 16-25,42-49,58-61,85-92,139-146,161-175,183-197,205-215,220-225,388-391,427-431,438-441,449-465
AlphaFold
Disorder 1-199,217-217,220-277,382-395,427-469,607-611
Order 200-216,218-219,278-381,396-426,470-606,612-908
Pfam Hmmer
PF00855 285-358 4.3e-34
PF00145 630-903 3.9e-08
SEG 2-13 ,15-37 ,109-124 ,160-177 ,204-215 ,412-430 ,438-453
Function
Function in SwissProt
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development (PubMed:9662389, PubMed:11399089, PubMed:10555141, PubMed:11919202, PubMed:16567415, PubMed:17713477). DNA methylation is coordinated with methylation of histones (PubMed:9662389, PubMed:11399089, PubMed:10555141, PubMed:11919202, PubMed:16567415, PubMed:17713477). It modifies DNA in a non-processive manner and also methylates non-CpG sites (PubMed:9662389, PubMed:11399089, PubMed:10555141, PubMed:11919202, PubMed:16567415, PubMed:17713477). May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1 (PubMed:18823905). Plays a role in paternal and maternal imprinting (PubMed:15215868). Required for methylation of most imprinted loci in germ cells (PubMed:15215868). Acts as a transcriptional corepressor for ZBTB18 (PubMed:11350943). Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites (PubMed:20547484). Can actively repress transcription through the recruitment of HDAC activity (PubMed:11350943). Also has weak auto-methylation activity on Cys-706 in absence of DNA (PubMed:21481189).