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IID50168
 UniprotP22216
ProteinSerine/threonine-protein kinase RAD53
GeneRAD53
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
821
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-164 Monomer :
 Evidence NMR 1k3j A Reference
       Region 1k3j A 14-164 order
       Region 1k3j A 14-27 high_rmsd
       Region 1k3j A 160-164 high_rmsd
 Evidence NMR 1j4o A Reference
       Region 1j4o A 14-164 order
 Evidence NMR 1g3g A Reference
       Region 1g3g A 1-164 order
       Region 1g3g A 1-27 high_rmsd
       Region 1g3g A 58-58 high_rmsd
       Region 1g3g A 159-164 high_rmsd
Seq 1-466 Monomer :
 Evidence X-RAY 5xzw B Reference
       Region 5xzw B 1-31 disorder
       Region 5xzw B 32-157 order
       Region 5xzw B 158-188 disorder
       Region 5xzw B 189-342 order
       Region 5xzw B 343-353 disorder
       Region 5xzw B 354-368 order
       Region 5xzw B 369-383 disorder
       Region 5xzw B 384-466 order
 Evidence X-RAY 5xzw A Reference
       Region 5xzw A 1-14 disorder
       Region 5xzw A 15-78 order
       Region 5xzw A 79-86 disorder
       Region 5xzw A 87-134 order
       Region 5xzw A 135-137 disorder
       Region 5xzw A 138-164 order
       Region 5xzw A 165-190 disorder
       Region 5xzw A 191-343 order
       Region 5xzw A 344-356 disorder
       Region 5xzw A 357-367 order
       Region 5xzw A 368-382 disorder
       Region 5xzw A 383-408 order
       Region 5xzw A 409-410 disorder
       Region 5xzw A 411-425 order
       Region 5xzw A 426-428 disorder
       Region 5xzw A 429-446 order
       Region 5xzw A 447-449 disorder
       Region 5xzw A 450-465 order
       Region 5xzw A 466-466 disorder
 Evidence X-RAY 5xzv B Reference
       Region 5xzv B 1-31 disorder
       Region 5xzv B 32-134 order
       Region 5xzv B 135-139 disorder
       Region 5xzv B 140-157 order
       Region 5xzv B 158-188 disorder
       Region 5xzv B 189-233 order
       Region 5xzv B 234-237 disorder
       Region 5xzv B 238-342 order
       Region 5xzv B 343-353 disorder
       Region 5xzv B 354-368 order
       Region 5xzv B 369-382 disorder
       Region 5xzv B 383-466 order
 Evidence X-RAY 5xzv A Reference
       Region 5xzv A 1-15 disorder
       Region 5xzv A 16-78 order
       Region 5xzv A 79-84 disorder
       Region 5xzv A 85-134 order
       Region 5xzv A 135-137 disorder
       Region 5xzv A 138-164 order
       Region 5xzv A 165-189 disorder
       Region 5xzv A 190-344 order
       Region 5xzv A 345-358 disorder
       Region 5xzv A 359-367 order
       Region 5xzv A 368-382 disorder
       Region 5xzv A 383-408 order
       Region 5xzv A 409-410 disorder
       Region 5xzv A 411-424 order
       Region 5xzv A 425-429 disorder
       Region 5xzv A 430-446 order
       Region 5xzv A 447-449 disorder
       Region 5xzv A 450-453 order
       Region 5xzv A 454-455 disorder
       Region 5xzv A 456-465 order
       Region 5xzv A 466-466 disorder
Seq 3-12 Hetero dimer : IID50174Complex
 Evidence NMR 2jql B Reference
       Region 2jql B 3-12 order
Seq 3-12,14-164 Hetero dimer :
 Evidence NMR 2jqi B Reference
       Region 2jqi B 3-12 order
 Evidence NMR 2jqi A Reference
       Region 2jqi A 14-164 order
       Region 2jqi A 14-27 high_rmsd
       Region 2jqi A 160-164 high_rmsd
Seq 14-164 Hetero dimer : IID50186Complex
 Evidence NMR 2a0t A Reference
       Region 2a0t A 14-164 order
       Region 2a0t A 14-27 high_rmsd
       Region 2a0t A 159-164 high_rmsd
Seq 14-164 Hetero dimer : IID50198Complex
 Evidence NMR 1k3n A Reference
       Region 1k3n A 14-164 order
       Region 1k3n A 14-27 high_rmsd
       Region 1k3n A 160-164 high_rmsd
 Evidence NMR 1j4p A Reference
       Region 1j4p A 14-164 order
Seq 14-164 Hetero dimer : IID50198Complex
 Evidence NMR 1k3q A Reference
       Region 1k3q A 14-164 order
       Region 1k3q A 14-27 high_rmsd
       Region 1k3q A 160-164 high_rmsd
 Evidence NMR 1j4q A Reference
       Region 1j4q A 14-164 order
Seq 22-162 Monomer : P32325
 Evidence X-RAY 5t2f A Reference
       Region 5t2f A 22-29 disorder
       Region 5t2f A 30-155 order
       Region 5t2f A 156-162 disorder
Seq 22-162 Hetero dimer : P06243,P32325
 Evidence X-RAY 5t2s A Reference
       Region 5t2s A 22-27 disorder
       Region 5t2s A 28-159 order
       Region 5t2s A 160-162 disorder
Seq 22-162 Monomer : P32325
 Evidence X-RAY 5t2f C Reference
       Region 5t2f C 22-28 disorder
       Region 5t2f C 29-159 order
       Region 5t2f C 160-162 disorder
Seq 22-162 Monomer : P32325
 Evidence X-RAY 5t2f B Reference
       Region 5t2f B 22-27 disorder
       Region 5t2f B 28-157 order
       Region 5t2f B 158-162 disorder
Seq 22-162 Monomer : P32325
 Evidence X-RAY 5t2f D Reference
       Region 5t2f D 22-28 disorder
       Region 5t2f D 29-159 order
       Region 5t2f D 160-162 disorder
Seq 22-162 Hetero dimer : P06243,P32325
 Evidence X-RAY 5t2s C Reference
       Region 5t2s C 22-28 disorder
       Region 5t2s C 29-157 order
       Region 5t2s C 158-162 disorder
Seq 29-155 Hetero tetramer :
 Evidence X-RAY 1g6g B Reference
       Region 1g6g B 29-31 disorder
       Region 1g6g B 32-155 order
 Evidence X-RAY 1g6g A Reference
       Region 1g6g A 29-155 order
Seq 170-512 Homo dimer :
 Evidence X-RAY 4pds B Reference
       Region 4pds B 170-190 disorder
       Region 4pds B 191-200 order
       Region 4pds B 201-209 disorder
       Region 4pds B 210-229 order
       Region 4pds B 230-240 disorder
       Region 4pds B 241-263 order
       Region 4pds B 264-268 disorder
       Region 4pds B 269-345 order
       Region 4pds B 346-357 disorder
       Region 4pds B 358-367 order
       Region 4pds B 368-382 disorder
       Region 4pds B 383-471 order
       Region 4pds B 472-475 disorder
       Region 4pds B 476-494 order
       Region 4pds B 495-512 disorder
 Evidence X-RAY 4pds A Reference
       Region 4pds A 170-190 disorder
       Region 4pds A 191-203 order
       Region 4pds A 204-210 disorder
       Region 4pds A 211-229 order
       Region 4pds A 230-240 disorder
       Region 4pds A 241-263 order
       Region 4pds A 264-266 disorder
       Region 4pds A 267-345 order
       Region 4pds A 346-359 disorder
       Region 4pds A 360-368 order
       Region 4pds A 369-381 disorder
       Region 4pds A 382-471 order
       Region 4pds A 472-474 disorder
       Region 4pds A 475-490 order
       Region 4pds A 491-512 disorder
 Evidence X-RAY 4pdp B Reference
       Region 4pdp B 170-190 disorder
       Region 4pdp B 191-206 order
       Region 4pdp B 207-209 disorder
       Region 4pdp B 210-231 order
       Region 4pdp B 232-238 disorder
       Region 4pdp B 239-265 order
       Region 4pdp B 266-267 disorder
       Region 4pdp B 268-346 order
       Region 4pdp B 347-357 disorder
       Region 4pdp B 358-367 order
       Region 4pdp B 368-382 disorder
       Region 4pdp B 383-471 order
       Region 4pdp B 472-474 disorder
       Region 4pdp B 475-496 order
       Region 4pdp B 497-512 disorder
 Evidence X-RAY 4pdp A Reference
       Region 4pdp A 170-190 disorder
       Region 4pdp A 191-200 order
       Region 4pdp A 201-209 disorder
       Region 4pdp A 210-233 order
       Region 4pdp A 234-237 disorder
       Region 4pdp A 238-265 order
       Region 4pdp A 266-267 disorder
       Region 4pdp A 268-346 order
       Region 4pdp A 347-357 disorder
       Region 4pdp A 358-368 order
       Region 4pdp A 369-381 disorder
       Region 4pdp A 382-471 order
       Region 4pdp A 472-475 disorder
       Region 4pdp A 476-494 order
       Region 4pdp A 495-512 disorder
Seq 549-730 Monomer :
 Evidence NMR 1qu5 A Reference
       Region 1qu5 A 549-730 order
       Region 1qu5 A 549-572 high_rmsd
       Region 1qu5 A 634-638 high_rmsd
 Evidence NMR 1fhq A Reference
       Region 1fhq A 573-730 order
       Region 1fhq A 573-573 high_rmsd
       Region 1fhq A 636-638 high_rmsd
       Region 1fhq A 710-712 high_rmsd
 Evidence NMR 1dmz A Reference
       Region 1dmz A 573-730 order
       Region 1dmz A 573-573 high_rmsd
       Region 1dmz A 634-638 high_rmsd
Seq 573-730 Hetero dimer : IID50198Complex
 Evidence NMR 1k2n A Reference
       Region 1k2n A 573-730 order
       Region 1k2n A 573-573 high_rmsd
       Region 1k2n A 636-638 high_rmsd
       Region 1k2n A 710-712 high_rmsd
 Evidence NMR 1j4l A Reference
       Region 1j4l A 573-730 order
Seq 573-730 Hetero dimer : IID50198Complex
 Evidence NMR 1k2m A Reference
       Region 1k2m A 573-730 order
       Region 1k2m A 637-638 high_rmsd
       Region 1k2m A 710-712 high_rmsd
 Evidence NMR 1j4k A Reference
       Region 1j4k A 573-730 order
 Evidence NMR 1fhr A Reference
       Region 1fhr A 573-730 order
       Region 1fhr A 573-573 high_rmsd
       Region 1fhr A 711-712 high_rmsd
Seq 800-821 Hetero dimer : IID50170Complex
 Evidence X-RAY 2ygv H Reference
       Region 2ygv H 800-802 disorder
       Region 2ygv H 803-809 order
       Region 2ygv H 810-818 disorder
       Region 2ygv H 819-821 order
 Evidence X-RAY 2ygv G Reference
       Region 2ygv G 800-801 disorder
       Region 2ygv G 802-809 order
       Region 2ygv G 810-815 disorder
       Region 2ygv G 816-821 order
 Evidence X-RAY 2ygv F Reference
       Region 2ygv F 800-802 disorder
       Region 2ygv F 803-812 order
       Region 2ygv F 813-818 disorder
       Region 2ygv F 819-821 order
 Evidence X-RAY 2ygv E Reference
       Region 2ygv E 800-802 disorder
       Region 2ygv E 803-821 order
Seqphosphorylation
    560-560 Phosphoserine
    24-24 Phosphoserine
    175-175 Phosphoserine
    547-547 Phosphoserine
    774-774 Phosphoserine
    793-793 Phosphoserine
 
Prediction
NeProc
Disorder 1-27,158-190,479-489,518-577,713-821
Order 28-157,191-374,382-478,490-517,578-638,644-712
ProS 1-10,158-168,489-489,528-549,556-557,559-565,573-577,713-730,747-750,759-789,804-821
AlphaFold
Disorder 1-14,163-189,208-208,235-241,243-244,341-358,369-383,469-481,486-486,519-575,630-644,698-713,733-821
Order 15-162,190-207,209-234,242-242,245-340,359-368,384-468,482-485,487-518,576-629,645-697,714-732
Pfam Hmmer
PF00498 66-133 3.7e-13
PF00069 198-466 1.1e-114
PF00498 601-681 5.7e-11
SEG 5-16 ,91-104 ,480-494 ,511-526 ,742-771
Function
Function in SwissProt
Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. Seems to be involved in the phosphorylation of RPH1.