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IID50171
 UniprotP32505
ProteinNuclear polyadenylated RNA-binding protein NAB2
GeneNAB2
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
525
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-105 Hetero dimer : IID50178Complex
 Evidence X-RAY 3lcn B Reference
       Region 3lcn B 1-3 disorder
       Region 3lcn B 4-100 order
       Region 3lcn B 101-105 disorder
 Evidence X-RAY 3lcn A Reference
       Region 3lcn A 1-4 disorder
       Region 3lcn A 5-100 order
       Region 3lcn A 101-105 disorder
Seq 1-105 Monomer :
 Evidence NMR 2jps A Reference
       Region 2jps A 1-105 order
       Region 2jps A 1-1 high_rmsd
       Region 2jps A 101-105 high_rmsd
 Evidence X-RAY 2v75 A Reference
       Region 2v75 A 1-5 disorder
       Region 2v75 A 6-94 order
       Region 2v75 A 95-104 disorder
Seq 205-242 Hetero dimer : IID00094Complex
 Evidence X-RAY 4jlq B Reference
       Region 4jlq B 205-233 disorder
       Region 4jlq B 234-240 order
       Region 4jlq B 241-242 disorder
Seq 253-333 Monomer :
 Evidence NMR 3zj1 A Reference
       Region 3zj1 A 253-333 order
       Region 3zj1 A 253-256 high_rmsd
       Region 3zj1 A 324-333 high_rmsd
Seq 333-401 Monomer :
 Evidence NMR 3zj2 A Reference
       Region 3zj2 A 333-401 order
       Region 3zj2 A 333-334 high_rmsd
       Region 3zj2 A 396-401 high_rmsd
Seq 409-483 Monomer :
 Evidence NMR 2lhn A Reference
       Region 2lhn A 409-483 order
       Region 2lhn A 483-483 high_rmsd
Seq 409-483 Homo tetramer :
 Evidence X-RAY 5l2l F Reference
       Region 5l2l F 409-481 order
       Region 5l2l F 482-483 disorder
 Evidence X-RAY 5l2l E Reference
       Region 5l2l E 409-480 order
       Region 5l2l E 481-483 disorder
 Evidence X-RAY 5l2l B Reference
       Region 5l2l B 409-480 order
       Region 5l2l B 481-483 disorder
 Evidence X-RAY 5l2l A Reference
       Region 5l2l A 409-479 order
       Region 5l2l A 480-483 disorder
SeqProS possible 235-238 Nuclear Localization Signal (NLS) Hetero dimer : IID00094Complex
       Region 4jlq B 234-240 order
Seqphosphorylation
    254-254 Phosphothreonine
 
Prediction
NeProc
Disorder 1-3,79-303,332-337,373-379,387-434,478-525
Order 4-78,304-331,338-359,367-372,380-386,435-477
ProS 185-190,251-255,261-303,373-379,414-426,478-487,494-503,522-525
AlphaFold
Disorder 1-1,98-237,240-240,242-242,244-257,330-336,394-408,480-492,498-498,504-506,509-509,511-525
Order 2-97,238-239,241-241,243-243,258-329,337-393,409-479,493-497,499-503,507-508,510-510
SEG 103-164 ,209-232 ,320-331
Function
Function in SwissProt
This essential protein binds to polyadenylated RNA and single-stranded DNA. It may be involved not only in RNA processing but also in transcription regulation. Believed to associate directly with nascent RNA polymerase II transcripts and remain associated during subsequent nuclear RNA processing reactions.