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IID50172
 UniprotP34160
ProteinNuclear cap-binding protein complex subunit 1
GeneSTO1
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
861
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1-30 Hetero dimer : IID50009Complex
 Evidence X-RAY 3uky C Reference
       Region 3uky C 1-2 disorder
       Region 3uky C 3-8 order
       Region 3uky C 9-22 disorder
       Region 3uky C 23-30 order
SeqProS possible 3-8,23-30 Nuclear Localization Signal (NLS) Hetero dimer : IID50009Complex
       Region 3uky C 3-8 order
       Region 3uky C 23-30 order
 
Prediction
NeProc
Disorder 1-29,294-310,622-626,771-801
Order 30-181,188-289,311-402,409-621,627-671,676-770,802-861
ProS 5-21,26-29,294-310,771-777
AlphaFold
Disorder 1-27,337-338,751-755,788-799
Order 28-336,339-750,756-787,800-861
Pfam Hmmer
PF02854 36-264 4.5e-33
SEG 750-763 ,792-806
Function
Function in SwissProt
Component of the CBC complex, which binds co-transcriptionally to the 5'-cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs. The CBC complex is required for efficient pre-mRNA splicing through efficient commitment complex and spliceosome formation. Together with NPL3, the CBC complex is required for export of mRNAs out of the nucleus. The CBC complex is also involved in nuclear mRNA degradation, probably by directing the mRNAs to the sites of degradation. Affects replication of the positive-strand RNA virus BMV.