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IID50177
 UniprotP97756
ProteinCalcium/calmodulin-dependent protein kinase kinase 1
GeneCamkk1
OrganismRattus norvegicus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
505
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 438-463 Hetero dimer : IID50309Complex
 Evidence NMR 1ckk B Reference
       Region 1ckk B 438-463 order
       Region 1ckk B 438-439 high_rmsd
Seqphosphorylation
    492-492 Phosphoserine
    475-475 Phosphoserine
    458-458 Phosphoserine
    108-108 Phosphothreonine
    100-100 Phosphoserine
    74-74 Phosphoserine
    67-67 Phosphoserine
 
Prediction
NeProc
Disorder 1-106,162-189,450-505
Order 107-161,190-449
ProS 1-22,39-42,68-76,162-171,450-465,486-501
AlphaFold
Disorder 1-106,119-122,138-139,167-190,425-429,436-447,459-505
Order 107-118,123-137,140-166,191-424,430-435,448-458
Pfam Hmmer
PF00069 128-409 3.1e-80
SEG 368-381 ,478-491
Function
Function in SwissProt
Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.
Biological Process
See also
Diagram with PDB data
Camk1/CALM1Solution structure of Ca2+/calmodulin complexed with a peptide representing the calmodulin-binding domain of calmodulin kinase I