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IID50181
 UniprotQ99LM3
ProteinSmoothelin-like protein 1
GeneSmtnl1
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
459
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 346-459 Hetero dimer : IID50309Complex
 Evidence NMR 2k3s A Reference
       Region 2k3s A 346-459 order
       Region 2k3s A 458-459 high_rmsd
Seq 346-459 Monomer :
 Evidence NMR 2jv9 A Reference
       Region 2jv9 A 346-459 order
       Region 2jv9 A 459-459 high_rmsd
Seqphosphorylation
    301-301 Phosphoserine; by PKA and PKG
 
Prediction
NeProc
Disorder 1-126,155-344,452-459
Order 127-154,345-451
ProS 452-456
AlphaFold
Disorder 1-74,82-342,456-459
Order 75-81,343-455
Pfam Hmmer
PF00307 344-449 3.3e-30
SEG 56-72 ,218-230 ,236-246 ,260-285
Function
Function in SwissProt
Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-301 reduces this inhibitory activity.