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IID50185
 UniprotP26675
ProteinProtein son of sevenless
GeneSos
OrganismDrosophila melanogaster
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
1596
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 1342-1350 Hetero dimer : IID00459Complex
 Evidence NMR 1aze B Reference
       Region 1aze B 1342-1350 order
Seqphosphorylation
    1551-1551 Phosphoserine
    1550-1550 Phosphoserine
 
Prediction
NeProc
Disorder 1-54,231-244,516-527,601-609,699-721,794-812,1072-1596
Order 55-230,245-515,528-600,610-698,722-793,813-816,821-1071
ProS 1-27,699-702,710-721,800-806,1072-1090,1163-1169,1345-1350,1366-1379,1385-1399,1414-1430,1553-1596
AlphaFold
Disorder 1-57,131-132,148-148,220-220,224-224,227-246,318-319,439-450,473-473,475-476,493-494,517-526,562-562,633-637,699-718,794-807,1092-1596
Order 58-130,133-147,149-219,221-223,225-226,247-317,320-438,451-472,474-474,477-492,495-516,527-561,563-632,638-698,719-793,808-1091
Pfam Hmmer
PF00125 146-219 3.4e-07
PF00621 252-429 1.4e-69
PF00169 481-588 9.8e-16
PF00618 640-768 3.3e-46
PF00617 826-1010 2.5e-95
SEG 15-48 ,700-713 ,1096-1129 ,1138-1153 ,1213-1224 ,1255-1266 ,1433-1444 ,1463-1490 ,1512-1517 ,1525-1542
Function
Function in SwissProt
Promotes the exchange of Ras-bound GDP by GTP. Functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases; implies a role for the ras pathway in neuronal development.