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IID50191
 UniprotO09110
ProteinDual specificity mitogen-activated protein kinase kinase 3
GeneMap2k3
OrganismMus musculus
Sequence LLPS PhaSepDB
PhaSePro
LLPSDB
DrLLPS
 Network xml rdf
Structure
Experiment
  :order   disorder   conflict   PDB cluster   ProS   Pfam Domain   SEG
347
 order/disorder by at least rule
     disorder by at least rule
     order by at least rule
 order/disorder by majority rule
Seq 16-32 Hetero dimer : IID50045Complex
 Evidence X-RAY 1lez B Reference
       Region 1lez B 16-21 disorder
       Region 1lez B 22-29 order
       Region 1lez B 30-32 disorder
SeqProS predicted 22-29 The unbound state of this region is deduced to be disordered based on the results of prediction tools (DICHOT, Mobi, d2p2 etc). Hetero dimer : IID50045Complex
       Region 1lez B 22-29 order
Seqphosphorylation
    3-3 Phosphoserine
    218-218 Phosphoserine
    222-222 Phosphothreonine
Seqacetylation
    1-1 N-acetylmethionine
 
Prediction
NeProc
Disorder 1-42
Order 43-347
ProS 21-28
AlphaFold
Disorder 1-46,74-74,98-100,212-213,215-227,238-238,240-245,272-272,346-347
Order 47-73,75-97,101-211,214-214,228-237,239-239,246-271,273-345
Pfam Hmmer
PF00069 64-325 3.2e-53
SEG 3-11
Function
Function in SwissProt
Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14.